Penetration of cefuroxime into the cerebrospinal fluid of patients with traumatic brain injury

T Kossmann; V Hans; R Stocker; H G Imhof; B Joos; O Trentz; M C Morganti-Kossmann

doi:10.1093/jac/37.1.161

Penetration of cefuroxime into the cerebrospinal fluid of patients with traumatic brain injury

J Antimicrob Chemother. 1996 Jan;37(1):161-7. doi: 10.1093/jac/37.1.161.

Authors

T Kossmann¹, V Hans, R Stocker, H G Imhof, B Joos, O Trentz, M C Morganti-Kossmann

Affiliation

¹ Department of Surgery, University of Zürich, Medical School, Switzerland.

PMID: 8647759
DOI: 10.1093/jac/37.1.161

Abstract

Cefuroxime levels were measured in cerebrospinal fluid (CSF) and serum of four patients with traumatic brain injury following the implantation of intraventricular catheters. The levels ranged from 0.15 to 2.03 micrograms/mL in CSF and from 1.8 to 66.9 micrograms/mL in serum. No ventriculostomy related infections were detected.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adolescent
Adult
Antibiotic Prophylaxis*
Blood-Brain Barrier
Brain Injuries / cerebrospinal fluid*
Cefuroxime / cerebrospinal fluid*
Cephalosporins / cerebrospinal fluid*
Female
Humans
Male

Substances

Cephalosporins
Cefuroxime