Antibacterial activity of the phenolic acids fractions of Scrophularia frutescens and Scrophularia sambucifolia

J Ethnopharmacol. 1996 Jul 26;53(1):11-4. doi: 10.1016/0378-8741(96)01419-5.

Abstract

The phenolic fractions of aerial part of Scrophularia frutescens and S. sambucifolia (Scrophulariaceae) showed a potent antibacterial activity. Ferulic, isovanillic, p-hydroxycinnamic, p-hydroxybenzoic, syringic, caffeic, gentisic and protocatechuic acids were isolated from S. frutescens and ferulic, p-coumaric, vanillic, p-hydroxibenzoic and syringic acids were isolated from S. sambucifolia. Since phenolic acids have been shown in the literature to exert an antibacterial effect, the presence of these compounds in the two plants explains their antibacterial activity.

MeSH terms

  • Anti-Bacterial Agents / isolation & purification*
  • Anti-Bacterial Agents / metabolism
  • Anti-Bacterial Agents / pharmacology
  • Bacillus / drug effects
  • Bacillus / metabolism
  • Caffeic Acids / isolation & purification
  • Caffeic Acids / metabolism
  • Caffeic Acids / pharmacology
  • Chemical Fractionation
  • Coumaric Acids / isolation & purification
  • Coumaric Acids / metabolism
  • Coumaric Acids / pharmacology
  • Escherichia coli / drug effects
  • Escherichia coli / metabolism
  • Free Radical Scavengers / isolation & purification
  • Free Radical Scavengers / metabolism
  • Free Radical Scavengers / pharmacology
  • Gallic Acid / analogs & derivatives
  • Gallic Acid / isolation & purification
  • Gallic Acid / metabolism
  • Gallic Acid / pharmacology
  • Gentisates*
  • Hydroxybenzoates / isolation & purification
  • Hydroxybenzoates / metabolism
  • Hydroxybenzoates / pharmacology
  • Moraxella / drug effects
  • Moraxella / metabolism
  • Parabens / isolation & purification
  • Parabens / metabolism
  • Parabens / pharmacology
  • Plant Extracts / metabolism
  • Plant Extracts / pharmacology*
  • Plants, Medicinal
  • Propionates
  • Salmonella typhimurium / drug effects
  • Salmonella typhimurium / metabolism
  • Serratia marcescens / drug effects
  • Serratia marcescens / metabolism
  • Structure-Activity Relationship
  • Vanillic Acid / analogs & derivatives
  • Vanillic Acid / isolation & purification
  • Vanillic Acid / metabolism
  • Vanillic Acid / pharmacology

Substances

  • Anti-Bacterial Agents
  • Caffeic Acids
  • Coumaric Acids
  • Free Radical Scavengers
  • Gentisates
  • Hydroxybenzoates
  • Parabens
  • Plant Extracts
  • Propionates
  • protocatechuic acid
  • Gallic Acid
  • isovanillic acid
  • ferulic acid
  • syringic acid
  • Vanillic Acid
  • p-coumaric acid
  • 4-hydroxybenzoic acid
  • caffeic acid
  • 2,5-dihydroxybenzoic acid