Abstract
The cytotoxic T-lymphocyte (CTL) response in reovirus-infected C3H mice was investigated by using reovirus-vaccinia virus recombinants. Results of cytotoxicity assays indicated that the nonstructural protein sigma1NS elicited a significant CTL response. Experiments with sigma1NS-specific CTL lines showed that both strain-specific and cross-reactive epitopes exist in the sigma1NS protein.
Publication types
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Research Support, U.S. Gov't, Non-P.H.S.
MeSH terms
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Animals
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Antigens, Viral / genetics
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Antigens, Viral / immunology*
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Base Sequence
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Cells, Cultured
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Cytotoxicity Tests, Immunologic
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Genetic Vectors
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L Cells
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Mammalian orthoreovirus 3 / genetics
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Mammalian orthoreovirus 3 / immunology*
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Mice
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Mice, Inbred C3H
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Molecular Sequence Data
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T-Lymphocytes, Cytotoxic / cytology
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T-Lymphocytes, Cytotoxic / immunology*
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Vaccinia virus / genetics
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Viral Nonstructural Proteins / genetics
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Viral Nonstructural Proteins / immunology*
Substances
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Antigens, Viral
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Viral Nonstructural Proteins
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sigma 1NS protein, Reovirus