Abstract
13-Deacetoxy-11-demethyl-phorbol derivatives with acyl groups of various lengths (from hexanoyl to tetradecanoyl) at the C-12 position were synthesized in an optically active form. Although considerable binding affinities to PKC were observed by analogs 3-7, no activation of PKC was seen even at 10 microM.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Binding, Competitive / drug effects
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Enzyme Activation / drug effects
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Phorbol 12,13-Dibutyrate / metabolism
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Phorbol Esters / chemical synthesis
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Phorbol Esters / metabolism*
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Protein Binding
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Protein Kinase C / metabolism*
Substances
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Phorbol Esters
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Phorbol 12,13-Dibutyrate
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Protein Kinase C