Genomic organization of the KTX2 gene, encoding a 'short' scorpion toxin active on K+ channels

FEBS Lett. 1997 Jan 27;402(1):45-9. doi: 10.1016/s0014-5793(96)01492-5.

Abstract

A single intron of 87 bp, close to the region encoding the C-terminal part of the signal peptide, was found in the gene of the 'short' scorpion toxin kaliotoxin 2 of Androctonus australis acting on various types of K+ channels. Its A+T content was particularly high (up to 86%). By walking and ligation-mediated PCR, the promoter sequences of the kaliotoxin 2 gene of Androctonus australis were studied. The transcription unit of the gene is 390 bp long. Consensus sequences were identified. The genes of 'short' scorpion toxins active on K+ channels are organized similarly to those of the 'long' scorpion toxins active on Na+ channels and not like those of structurally related insect defensins, which are intronless.

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Base Composition
  • Base Sequence
  • Consensus Sequence
  • DNA, Complementary
  • Introns
  • Molecular Sequence Data
  • Polymerase Chain Reaction
  • Potassium Channels / drug effects
  • Promoter Regions, Genetic*
  • Protein Precursors / genetics
  • Scorpion Venoms / chemistry
  • Scorpion Venoms / genetics*
  • Scorpion Venoms / pharmacology
  • Scorpions / genetics*

Substances

  • DNA, Complementary
  • Potassium Channels
  • Protein Precursors
  • Scorpion Venoms
  • kaliotoxin