Abstract
1. Elgodipine (ELG) had no significant effect on aortic content of cholesterol, plasma cholesterol, or triglycerides concentrations in cholesterol-fed rabbits. However, ELG administration produced a dose-dependent and significant reduction of calcium content of the aorta. 2. In vitro studies showed that ELG was able to inhibit vascular smooth muscle proliferation through a mechanism independent of the expression of the transcription factors c-fos and c-jun.
Publication types
-
Comparative Study
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Animals
-
Aorta, Thoracic / drug effects*
-
Aorta, Thoracic / metabolism
-
Arteriosclerosis / prevention & control
-
Blood Pressure / drug effects
-
Calcium / analysis
-
Calcium Channel Blockers / pharmacology*
-
Cell Division / drug effects
-
Cells, Cultured
-
Cholesterol, Dietary / administration & dosage
-
Dihydropyridines / pharmacology*
-
Gene Expression / drug effects
-
Hypercholesterolemia / blood
-
Hypercholesterolemia / metabolism
-
Lipoproteins / blood
-
Male
-
Muscle, Smooth, Vascular / drug effects*
-
Muscle, Smooth, Vascular / metabolism
-
Proto-Oncogene Proteins / biosynthesis
-
Rabbits
-
Triglycerides / blood
Substances
-
Calcium Channel Blockers
-
Cholesterol, Dietary
-
Dihydropyridines
-
Lipoproteins
-
Proto-Oncogene Proteins
-
Triglycerides
-
elgodipine
-
Calcium