Preparturient vaccination to enhance passive immunity to the capsular polysaccharide of Pasteurella haemolytica A1

Vet Immunol Immunopathol. 1996 Mar;50(1-2):67-77. doi: 10.1016/0165-2427(95)05493-6.

Abstract

The potential to increase passive serum antibody titres to a polysaccharide antigen in neonates, by preparturient vaccination of the dams was investigated. Dairy cows in five private herds were vaccinated with a commercial Pasteurella haemolytica culture supernatant vaccine (Presponse, Langford Inc.), at 6 and 3 weeks before their calculated due dates. Dams' sera, colostral whey, and post-colostral calf sera were assayed for antibodies of the IgG1 isotype binding purified capsular polysaccharide of P. haemolytica A1, using an enzyme immunoassay. Antibody titres were analyzed using the General Linear Model procedure (Statistical Analysis Systems Institute Inc.). Vaccinated dams had a significant increase in serum antibody titre after vaccination compared with non-vaccinates (P <0.01), and their antibody titres in colostral whey were significantly higher (P <0.05). Calves of vaccinated dams had significantly higher passive antibody titres than those of non-vaccinates (P <0.01) in all herds.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Animals, Newborn
  • Antibodies, Bacterial / blood
  • Bacterial Vaccines / administration & dosage
  • Cattle / immunology*
  • Cattle Diseases / immunology
  • Cattle Diseases / prevention & control
  • Colostrum / immunology
  • Female
  • Immunity, Maternally-Acquired
  • Immunization, Passive / veterinary*
  • Immunoglobulin G / blood
  • Mannheimia haemolytica / immunology*
  • Pasteurella Infections / immunology
  • Pasteurella Infections / prevention & control
  • Pasteurella Infections / veterinary
  • Polysaccharides, Bacterial / immunology*
  • Pregnancy

Substances

  • Antibodies, Bacterial
  • Bacterial Vaccines
  • Immunoglobulin G
  • Polysaccharides, Bacterial