Abstract
New thiophene carboxamide derivatives 3 (a-j) were synthesized as serotonin 5-HT4 receptor agonists. Preliminary results showed that the compounds 3a, 3d, 3e and 3f caused concentration dependent relaxation of carbachol-induced contraction in tunica muscularis mucosae in rat oesophagus.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Carbachol / antagonists & inhibitors
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Carbachol / pharmacology
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Esophagus / drug effects
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Esophagus / metabolism
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In Vitro Techniques
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Magnetic Resonance Spectroscopy
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Male
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Muscarinic Agonists / pharmacology
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Muscle Relaxation / drug effects
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Muscle, Smooth / drug effects
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Muscle, Smooth / metabolism
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Rats
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Rats, Wistar
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Receptors, Serotonin / metabolism
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Serotonin Receptor Agonists / chemical synthesis*
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Serotonin Receptor Agonists / pharmacology
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Spectrophotometry, Infrared
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Thiophenes / chemical synthesis*
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Thiophenes / pharmacology
Substances
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Muscarinic Agonists
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Receptors, Serotonin
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Serotonin Receptor Agonists
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Thiophenes
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Carbachol