A large number of animal experimental data indicate that pre- or early postnatal malnutrition can have long-term negative consequences on weight and height, with smaller weight and height in adulthood than predicted on genetics basis. Furthermore, according to the Barker's hypothesis, based on data available from British cohort studies, in utero malnutrition could also result in an increased risk of cardiovascular, endocrine and metabolic diseases in adulthood. There are however discordant data in the literature which invite to be cautious about on this hypothesis, mainly because the role of the socio-economic factors during childhood and adulthood have not been taken into account.