212 cases of valve replacement with giant heart were followed up for 0.2-15.7 years (mean 3.23 years). There were 21 late deaths. The total survival rate was 91.3%, 80.6%, 74.3% at the 3rd, 6th and 9th year after operation, respectively, and the symptomatic remission rate was 84.4%, 70.6%, 56.8%, respectively. In patients with left atrium and right cardiac enlargement, the survival rate and symptomatic remission rate was significantly higher than those of left ventricle and total cardiac enlargement. The factors influencing late surgical result was discussed.