Abstract
IGF-I has been shown to enhance neuronal survival and inhibit apoptosis. IGF-I immunoreactivity was examined in the Alzheimer's disease and normal post-mortem human hippocampus and temporal cortex to determine whether IGF-I protein levels are altered in response to neurodegeneration. IGF-I immunoreactivity was induced in a subpopulation of GFAP-immunopositive astroglia in the Alzheimer's disease temporal cortex. These observations raise the possibility that IGF-I has a neuroprotective role in the Alzheimer's disease brain.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Aged
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Aged, 80 and over
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Alzheimer Disease / metabolism
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Alzheimer Disease / pathology*
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Antibodies, Monoclonal
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Astrocytes / cytology
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Astrocytes / metabolism
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Astrocytes / pathology
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Cross Reactions
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Female
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Glial Fibrillary Acidic Protein / analysis
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Hippocampus / cytology
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Hippocampus / metabolism
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Hippocampus / pathology*
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Humans
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Immunohistochemistry
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Insulin-Like Growth Factor I / analysis*
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Insulin-Like Growth Factor I / biosynthesis
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Male
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Middle Aged
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Neurons / cytology
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Neurons / metabolism
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Neurons / pathology
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Reference Values
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Temporal Lobe / cytology
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Temporal Lobe / metabolism
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Temporal Lobe / pathology*
Substances
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Antibodies, Monoclonal
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Glial Fibrillary Acidic Protein
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Insulin-Like Growth Factor I