Abstract
A beneficial consequence of screening for trisomy 21 by a combination of maternal age and fetal nuchal translucency thickness (NT) at 10-14 weeks is the early diagnosis of trisomy 18. In a multicenter study of 91,091 singleton pregnancies there were 106 fetuses with trisomy 18 and 83% were identified by NT screening. Trisomy 18 was also associated with early onset intrauterine growth retardation, decreased fetal heart rate and the presence of exomphalos.
Publication types
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Multicenter Study
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Research Support, Non-U.S. Gov't
MeSH terms
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Adolescent
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Adult
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Chromosomes, Human, Pair 18*
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Endosonography
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Exophthalmos / diagnostic imaging
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Female
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Fetal Diseases / diagnostic imaging*
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Fetal Diseases / genetics
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Fetal Diseases / physiopathology
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Gestational Age
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Heart Rate, Fetal
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Humans
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Pregnancy
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Pregnancy Trimester, First
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Retrospective Studies
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Sensitivity and Specificity
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Trisomy / diagnosis*
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Trisomy / genetics
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Trisomy / physiopathology
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Ultrasonography, Prenatal*
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Vagina / diagnostic imaging