Abstract
The purpose of the study is to examine the effect of GP during carcinogenesis of the golden hamster cheek pouches induced by DMBA. The results indicated that epithelial olysplasia and carcinoma in situ appeared respectively at 3 and 6 weeks. The formation of carcinoma was detected as early as 4 weeks which is earlier than that of former reports. The experiment proves that GP has positive anticarcinogenic function. Long-term observation in those the DMBA has been applied for 3 weeks found that epithelial dysplasia could reverse when GP was given. A compound prescription is better than GP alone.
MeSH terms
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9,10-Dimethyl-1,2-benzanthracene
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Animals
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Antineoplastic Agents, Phytogenic / therapeutic use*
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Carcinoma in Situ / chemically induced
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Carcinoma in Situ / prevention & control*
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Cricetinae
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Drugs, Chinese Herbal / therapeutic use*
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Leukoplakia, Oral / chemically induced
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Leukoplakia, Oral / prevention & control
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Mesocricetus
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Mouth Neoplasms / chemically induced
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Mouth Neoplasms / prevention & control*
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Precancerous Conditions / chemically induced
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Precancerous Conditions / prevention & control*
Substances
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Antineoplastic Agents, Phytogenic
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Drugs, Chinese Herbal
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9,10-Dimethyl-1,2-benzanthracene