Abstract
An A1400G mutation of the rrs gene was identified in Mycobacterium tuberculosis (MTB) strain ATCC 35827 and in 13 MTB clinical isolates resistant to amikacin-kanamycin (MICs, >128 microg/ml). High-level cross-resistance may result from such a mutation since MTB has a single copy of the rrs gene. Another mechanism(s) may account for high-level amikacin-kanamycin resistance in two mutants and lower levels of resistance in four clinical isolates, all lacking the A1400G mutation.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Amikacin / pharmacology
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Antitubercular Agents / pharmacology*
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Drug Resistance, Multiple / genetics*
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Drug Therapy, Combination / pharmacology*
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Genes, Bacterial / drug effects
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Genes, Bacterial / genetics*
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Humans
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Kanamycin / pharmacology
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Kanamycin Resistance / genetics*
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Mutation / genetics
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Mycobacterium tuberculosis / drug effects
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Mycobacterium tuberculosis / genetics*
Substances
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Antitubercular Agents
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Kanamycin
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Amikacin