Recovering and reamplifying of the differentially expressed cDNA bands isolated from mRNA differential display. A modified method

Mol Biotechnol. 1998 Apr;9(2):171-3. doi: 10.1007/BF02760818.

Abstract

Methods for retrieving and reamplifying the differentially expressed cDNA bands have been modified. Direct reamplification of differentially expressed bands after cutting from a polyacrylamide gel (PAG) followed by a simple rinse and crush step has proved to be more convenient and effective than the traditional glycogen-precipitation method. Combination of 30 cycles of differential display (DD) polymerase chain reaction (PCR) and 20 cycles of standard PCR reaction also yielded higher reamplification rates.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • DNA, Complementary / genetics*
  • DNA, Complementary / isolation & purification
  • Polymerase Chain Reaction / methods*
  • RNA, Messenger / genetics*

Substances

  • DNA, Complementary
  • RNA, Messenger