Abstract
The complete genome sequence of Treponema pallidum was determined and shown to be 1,138,006 base pairs containing 1041 predicted coding sequences (open reading frames). Systems for DNA replication, transcription, translation, and repair are intact, but catabolic and biosynthetic activities are minimized. The number of identifiable transporters is small, and no phosphoenolpyruvate:phosphotransferase carbohydrate transporters were found. Potential virulence factors include a family of 12 potential membrane proteins and several putative hemolysins. Comparison of the T. pallidum genome sequence with that of another pathogenic spirochete, Borrelia burgdorferi, the agent of Lyme disease, identified unique and common genes and substantiates the considerable diversity observed among pathogenic spirochetes.
Publication types
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Bacterial Proteins / genetics
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Bacterial Proteins / metabolism
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Base Sequence
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Borrelia burgdorferi Group / genetics
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Carrier Proteins / genetics
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Carrier Proteins / metabolism
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DNA Repair / genetics
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DNA Replication / genetics
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DNA Restriction Enzymes / genetics
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Energy Metabolism / genetics
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Genes, Bacterial
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Genes, Regulator
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Genome, Bacterial*
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Heat-Shock Response / genetics
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Lipoproteins / genetics
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Membrane Proteins / genetics
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Molecular Sequence Data
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Movement
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Open Reading Frames
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Oxygen Consumption / genetics
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Protein Biosynthesis
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Recombination, Genetic
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Replication Origin
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Sequence Analysis, DNA*
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Transcription, Genetic
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Treponema pallidum / genetics*
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Treponema pallidum / metabolism
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Treponema pallidum / pathogenicity
Substances
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Bacterial Proteins
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Carrier Proteins
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Lipoproteins
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Membrane Proteins
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DNA Restriction Enzymes
Associated data
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GENBANK/AE001185
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GENBANK/AE001186
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GENBANK/AE001187
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GENBANK/AE001188
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GENBANK/AE001189
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GENBANK/AE001190
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GENBANK/AE001191
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GENBANK/AE001192
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GENBANK/AE001193
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GENBANK/AE001194
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GENBANK/AE001195
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GENBANK/AE001196
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GENBANK/AE001197
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GENBANK/AE001198
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GENBANK/AE001199
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GENBANK/AE001200
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GENBANK/AE001201
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GENBANK/AE001202
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GENBANK/AE001203
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GENBANK/AE001204
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GENBANK/AE001205
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GENBANK/AE001206
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GENBANK/AE001207
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GENBANK/AE001208
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GENBANK/AE001209
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GENBANK/AE001210
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GENBANK/AE001211
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GENBANK/AE001212
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GENBANK/AE001213
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GENBANK/AE001214