Deregulated expression of the TAL1 gene by t(1;5)(p32;31) in patient with T-cell acute lymphoblastic leukemia

Genes Chromosomes Cancer. 1998 Sep;23(1):36-43. doi: 10.1002/(sici)1098-2264(199809)23:1<36::aid-gcc6>3.0.co;2-7.

Abstract

TAL1 gene deregulation is frequent in T-cell acute lymphoblastic leukemia (T-ALL) and can result from translocations involving 1p32 or, more frequently, from a cytogenetically undetectable interstitial deletion of chromosome 1. This study presents a case of T-ALL with a t(1;5)(p32;q31) involving TAL1, in which the breakpoint occurs approximately 10kbp 5' to the gene and leads to transcriptional activation and synthesis of a TAL1 protein, and extends the spectrum of recognized TAL1 gene translocations associated with T-ALL.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Basic Helix-Loop-Helix Transcription Factors
  • Chromosomes, Human, Pair 1 / genetics*
  • Chromosomes, Human, Pair 5 / genetics*
  • DNA, Neoplasm / analysis
  • DNA, Neoplasm / genetics
  • DNA, Neoplasm / isolation & purification
  • DNA-Binding Proteins / genetics*
  • Gene Expression / genetics
  • Gene Expression Regulation, Neoplastic
  • Humans
  • Karyotyping
  • Leukemia-Lymphoma, Adult T-Cell / genetics*
  • Male
  • Proto-Oncogene Proteins / genetics
  • RNA, Messenger / analysis
  • RNA, Messenger / genetics
  • T-Cell Acute Lymphocytic Leukemia Protein 1
  • Transcription Factors*
  • Translocation, Genetic*

Substances

  • Basic Helix-Loop-Helix Transcription Factors
  • DNA, Neoplasm
  • DNA-Binding Proteins
  • Proto-Oncogene Proteins
  • RNA, Messenger
  • T-Cell Acute Lymphocytic Leukemia Protein 1
  • Transcription Factors
  • TAL1 protein, human