Abstract
In a prior report, we described the isolation and characterization of SIVrcm, a distinct primate lentivirus found in a household pet Red-Capped Mangabey (RCM) in Gabon. SIVrcm is divergent from HIV-1 and HIV-2/SIV families of primate lentiviruses. In this report, additional in vitro replication studies and the results of SIVrcm infection in macaques are presented. SIVrcm causes little cytopathic effedct in Molt 4 Clone 8 cells and in rhesus and human PBMCs. In vivo, SIVrcm is non-pathogenic after 200 days in rhesus macaques and after one year in cynomolgous macaques, but does cause a chronic infection in both macaques.
Publication types
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Acquired Immunodeficiency Syndrome / immunology
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Acquired Immunodeficiency Syndrome / physiopathology
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Animals
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Animals, Domestic
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Antibody Formation
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CD4 Lymphocyte Count
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CD4-Positive T-Lymphocytes / immunology
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CD8-Positive T-Lymphocytes / immunology
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Cercocebus / virology*
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DNA, Viral / isolation & purification
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Gabun
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HIV-1 / genetics
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HIV-2 / genetics
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Humans
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Lymphocyte Count
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Macaca fascicularis
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Polymerase Chain Reaction
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Simian Acquired Immunodeficiency Syndrome / immunology
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Simian Acquired Immunodeficiency Syndrome / physiopathology*
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Simian Acquired Immunodeficiency Syndrome / virology
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Simian Immunodeficiency Virus / genetics
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Simian Immunodeficiency Virus / isolation & purification
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Simian Immunodeficiency Virus / physiology*
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T-Lymphocyte Subsets / immunology*
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Virus Replication*