Mapping of a new target region of allelic loss to a 6-cM interval at 21q21 in primary breast cancers

K Ohgaki; A Iida; F Kasumi; G Sakamoto; M Akimoto; Y Nakamura; M Emi

Mapping of a new target region of allelic loss to a 6-cM interval at 21q21 in primary breast cancers

Genes Chromosomes Cancer. 1998 Nov;23(3):244-7.

Authors

K Ohgaki¹, A Iida, F Kasumi, G Sakamoto, M Akimoto, Y Nakamura, M Emi

Affiliation

¹ Department of Molecular Biology, Institute of Gerontology, Nippon Medical School, Kawasaki, Japan.

PMID: 9790505

Abstract

A detailed analysis of loss of heterozygosity (LOH) in breast cancers was performed with 11 microsatellite markers on the long arm of chromosome 21. Among the 142 tumors examined, 44 (31%) showed LOH at one or more loci. Peak LOH frequency was observed on band 21q21. Deletion mapping identified a new commonly deleted region in a 6-cM interval of 21q21 between loci D21S1432 and D21S1437, and raised the possibility that one or more tumor suppressor genes associated with breast cancer may exist in this region. Comparison of these alterations with clinicopathological parameters revealed an association of LOH on 21q with loss of progesterone receptor (P = 0.0013).

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Breast Neoplasms / genetics*
Chromosome Deletion
Chromosomes, Human, Pair 21 / genetics*
Genes, Tumor Suppressor / genetics
Humans
Loss of Heterozygosity / genetics*
Microsatellite Repeats / genetics
Physical Chromosome Mapping
Receptors, Progesterone / genetics

Substances

Receptors, Progesterone