Glycosylated haemoglobin and hypertension arising in pregnancy

Br J Obstet Gynaecol. 1998 Oct;105(10):1122-4. doi: 10.1111/j.1471-0528.1998.tb09947.x.

Abstract

We analysed a database of glycosylated haemoglobin (HbA1) in nondiabetic pregnant women to investigate the relation between glucose metabolism in the first and second trimesters and hypertensive complications of pregnancy. From a total of 1334 women, 13 had pre-existing hypertension, 225 developed gestational hypertension and 51 developed pre-eclampsia. At 28 weeks of gestation, the women who subsequently developed gestational hypertension had a significantly higher mean HbA1 than those who remained normotensive (6.33 vs 6.17%, P < 0.02). This difference remained significant after correcting for the effects of age and body mass index (regression coefficient 0.11, SE 0.06, P = 0.05). In contrast, there were no significant differences in HbA1 between the women with pre-eclampsia and their normotensive counterparts. This provides indirect evidence to support our hypothesis that gestational hypertension is associated with insulin resistance but pre-eclampsia is not.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Blood Glucose / metabolism
  • Body Mass Index
  • Female
  • Glycated Hemoglobin / analysis*
  • Humans
  • Hypertension / metabolism*
  • Pregnancy
  • Pregnancy Complications, Cardiovascular / metabolism*
  • Pregnancy Trimester, First
  • Pregnancy Trimester, Second

Substances

  • Blood Glucose
  • Glycated Hemoglobin A