Abstract
Chromosome 2 of Plasmodium falciparum was sequenced; this sequence contains 947,103 base pairs and encodes 210 predicted genes. In comparison with the Saccharomyces cerevisiae genome, chromosome 2 has a lower gene density, introns are more frequent, and proteins are markedly enriched in nonglobular domains. A family of surface proteins, rifins, that may play a role in antigenic variation was identified. The complete sequencing of chromosome 2 has shown that sequencing of the A+T-rich P. falciparum genome is technically feasible.
Publication types
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Research Support, U.S. Gov't, Non-P.H.S.
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Amino Acid Sequence
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Animals
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Antigens, Protozoan / chemistry
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Antigens, Protozoan / genetics
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Base Composition
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Chromosomes / genetics*
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Evolution, Molecular
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Genes, Protozoan*
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Genome, Protozoan
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Introns
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Membrane Proteins / chemistry
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Membrane Proteins / genetics
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Molecular Sequence Data
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Multigene Family
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Physical Chromosome Mapping
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Plasmodium falciparum / genetics*
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Protozoan Proteins / chemistry
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Protozoan Proteins / genetics*
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RNA, Protozoan / genetics
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RNA, Transfer, Glu / genetics
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Repetitive Sequences, Nucleic Acid
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Reverse Transcriptase Polymerase Chain Reaction
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Sequence Alignment
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Sequence Analysis, DNA*
Substances
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Antigens, Protozoan
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Membrane Proteins
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Protozoan Proteins
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RNA, Protozoan
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RNA, Transfer, Glu
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serine repeat antigen, Plasmodium
Associated data
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GENBANK/AE001364
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GENBANK/AE001365
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GENBANK/AE001366
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GENBANK/AE001367
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GENBANK/AE001368
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GENBANK/AE001369
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GENBANK/AE001370
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GENBANK/AE001371
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GENBANK/AE001372
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GENBANK/AE001373
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GENBANK/AE001374
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GENBANK/AE001375
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GENBANK/AE001376
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GENBANK/AE001377
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GENBANK/AE001378
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GENBANK/AE001379
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GENBANK/AE001380
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GENBANK/AE001381
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GENBANK/AE001382
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GENBANK/AE001383
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GENBANK/AE001384
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GENBANK/AE001385
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GENBANK/AE001386
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GENBANK/AE001387
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GENBANK/AE001388
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GENBANK/AE001389
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GENBANK/AE001390
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GENBANK/AE001391
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GENBANK/AE001392
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GENBANK/AE001393