Abstract
The synthesis and biological activity of the novel series of 1 beta-methylcarbapenems, 1 and 2 were described. Most compounds displayed high potent antibacterial activity. The best compound in this series, 2a (IH201; R2 = NH2) showed an excellent and a broad spectrum as well as high renal DHP-I stability. It also possessed good in vivo efficacy and high safety.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Anti-Infective Agents / chemical synthesis*
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Anti-Infective Agents / pharmacokinetics
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Anti-Infective Agents / pharmacology*
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Area Under Curve
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Carbapenems / chemical synthesis*
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Carbapenems / pharmacokinetics
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Carbapenems / pharmacology*
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Lethal Dose 50
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Mice
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Microbial Sensitivity Tests
Substances
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Anti-Infective Agents
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Carbapenems