Actinomycin D, C2 and VII, inhibitors of Grb2-SHC interaction produced by Streptomyces

Bioorg Med Chem Lett. 1998 Aug 4;8(15):2001-2. doi: 10.1016/s0960-894x(98)00345-x.

Abstract

Actinomycin D, C2 and VII, cyclic peptides, inhibited Grb2 SH2 domain association (IC50 5-7 microM) with a phosphotyrosine containing peptide derived from the Shc protein (pTyr317). Actinomycins are the first examples of nonphosphorylated natural ligands of SH2 domain.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adaptor Proteins, Signal Transducing*
  • Dactinomycin / analogs & derivatives*
  • Dactinomycin / biosynthesis
  • Dactinomycin / chemistry
  • Dactinomycin / pharmacology*
  • GRB2 Adaptor Protein
  • Molecular Structure
  • Proteins / antagonists & inhibitors*
  • Spectrometry, Mass, Fast Atom Bombardment
  • Spectrophotometry, Ultraviolet
  • Streptomyces / metabolism*

Substances

  • Adaptor Proteins, Signal Transducing
  • GRB2 Adaptor Protein
  • Proteins
  • actinomycin VII
  • Dactinomycin
  • actinomycin C2