Abstract
Several new acetyl-4H,9H-naphtho[2,3-b]thiophene-4,9-diones were synthesized and evaluated for in vitro cytotoxicity by NCI against seven cancer cell types. 2,7-Diacetyl naphtho[2,3-b]thiophene-4,9-dione (9) showed significant cytotoxicity against leukemia cells with log GI50 values of -7.61 against SR cells and -7.18 against MOLT-4 cells. 3-Acetyl-naphtho[2,3-b]thiophene-4,9-dione (6) also demonstrated potent cytotoxicity in the latter cell line with log GI50 < -8.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Antineoplastic Agents / chemical synthesis*
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Antineoplastic Agents / pharmacology*
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Drug Screening Assays, Antitumor
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Humans
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KB Cells / drug effects
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Naphthols / chemical synthesis*
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Naphthols / pharmacology*
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Nuclear Magnetic Resonance, Biomolecular / methods
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Thiophenes / chemical synthesis*
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Thiophenes / pharmacology*
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Tumor Cells, Cultured
Substances
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Antineoplastic Agents
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Naphthols
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Thiophenes