Abstract
A tetrahydropyran-based inhibitor (2) of mammalian ribonucleotide reductase (mRR) has been designed and synthesized based on the heptapeptide, N-AcFTLDADF (1), corresponding to the C-terminus of the R2 subunit of mRR. Inhibition studies revealed that 2 is indeed a competent inhibitor, albeit less potent than 1.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Enzyme Inhibitors / chemical synthesis*
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Enzyme Inhibitors / pharmacology
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Models, Molecular
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Pyrans / chemical synthesis*
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Pyrans / pharmacology
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Ribonucleotide Reductases / antagonists & inhibitors*
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Structure-Activity Relationship
Substances
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Enzyme Inhibitors
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Pyrans
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Ribonucleotide Reductases