Evidence of phenotypic alteration as a cause of systolic dysfunction in the failing heart

Cardiol Clin. 1998 Nov;16(4):677-89, ix. doi: 10.1016/s0733-8651(05)70044-8.

Abstract

This article describes the phenotype of dilated cardiomyopathy in humans and describes parallel studies in experimental models that support or refute the relevance of these changes to the development of the heart failure phenotype.

Publication types

  • Review

MeSH terms

  • Adenylyl Cyclases / metabolism
  • Animals
  • Calcium / metabolism
  • Cardiomyopathy, Dilated / etiology*
  • Cardiomyopathy, Dilated / physiopathology
  • GTP-Binding Proteins / metabolism
  • Heart / physiopathology*
  • Homeostasis
  • Humans
  • Phenotype
  • Receptors, Adrenergic / physiology
  • Signal Transduction
  • Systole / physiology*

Substances

  • Receptors, Adrenergic
  • GTP-Binding Proteins
  • Adenylyl Cyclases
  • Calcium