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Chemotherapy targeted to tumor vasculature.
Arap W, Pasqualini R, Ruoslahti E. Arap W, et al. Curr Opin Oncol. 1998 Nov;10(6):560-5. doi: 10.1097/00001622-199811000-00014. Curr Opin Oncol. 1998. PMID: 9818236 Review.
Aminopeptidase N is a receptor for tumor-homing peptides and a target for inhibiting angiogenesis.
Pasqualini R, Koivunen E, Kain R, Lahdenranta J, Sakamoto M, Stryhn A, Ashmun RA, Shapiro LH, Arap W, Ruoslahti E. Pasqualini R, et al. Among authors: arap w. Cancer Res. 2000 Feb 1;60(3):722-7. Cancer Res. 2000. PMID: 10676659 Free PMC article.
A drug coupled to an NGR peptide has more potent antitumor effects than the free drug [W. Arap et al., Science (Washington DC), 279: 377-380, 1998]. We show here that the receptor for the NGR peptides in tumor vasculature is aminopeptidase N (APN; also called CD13). …
A drug coupled to an NGR peptide has more potent antitumor effects than the free drug [W. Arap et al., Science (Washington DC) …
Anti-cancer activity of targeted pro-apoptotic peptides.
Ellerby HM, Arap W, Ellerby LM, Kain R, Andrusiak R, Rio GD, Krajewski S, Lombardo CR, Rao R, Ruoslahti E, Bredesen DE, Pasqualini R. Ellerby HM, et al. Among authors: arap w. Nat Med. 1999 Sep;5(9):1032-8. doi: 10.1038/12469. Nat Med. 1999. PMID: 10470080
Integrin-binding peptides derived from phage display libraries.
Koivunen E, Restel BH, Rajotte D, Lahdenranta J, Hagedorn M, Arap W, Pasqualini R. Koivunen E, et al. Among authors: arap w. Methods Mol Biol. 1999;129:3-17. doi: 10.1385/1-59259-249-X:3. Methods Mol Biol. 1999. PMID: 10494554 No abstract available.
264 results