Stratford IJ - Search Results

1

Bioreductive activation of a series of indolequinones by human DT-diaphorase: structure-activity relationships.

Phillips RM, Naylor MA, Jaffar M, Doughty SW, Everett SA, Breen AG, Choudry GA, Stratford IJ. Phillips RM, et al. Among authors: stratford ij. J Med Chem. 1999 Oct 7;42(20):4071-80. doi: 10.1021/jm991063z. J Med Chem. 1999. PMID: 10514277

2

Pharmacological and biological evaluation of a series of substituted 1,4-naphthoquinone bioreductive drugs.

Phillips RM, Jaffar M, Maitland DJ, Loadman PM, Shnyder SD, Steans G, Cooper PA, Race A, Patterson AV, Stratford IJ. Phillips RM, et al. Among authors: stratford ij. Biochem Pharmacol. 2004 Dec 1;68(11):2107-16. doi: 10.1016/j.bcp.2004.08.007. Biochem Pharmacol. 2004. PMID: 15498501

3

2-Nitroimidazole dual-function bioreductive drugs: studies on the effects of regioisomerism and side-chain structural modifications on differential cytotoxicity and radiosensitization by aziridinyl and oxiranyl derivatives.

Naylor MA, Threadgill MD, Webb P, Stratford IJ, Stephens MA, Fielden EM, Adams GE. Naylor MA, et al. Among authors: stratford ij. J Med Chem. 1992 Sep 18;35(19):3573-8. doi: 10.1021/jm00097a015. J Med Chem. 1992. PMID: 1404237

4

2-Cyclopropylindoloquinones and their analogues as bioreductively activated antitumor agents: structure-activity in vitro and efficacy in vivo.

Naylor MA, Jaffar M, Nolan J, Stephens MA, Butler S, Patel KB, Everett SA, Adams GE, Stratford IJ. Naylor MA, et al. Among authors: stratford ij. J Med Chem. 1997 Jul 18;40(15):2335-46. doi: 10.1021/jm9608422. J Med Chem. 1997. PMID: 9240349

5

5-substituted analogues of 3-hydroxymethyl-5-aziridinyl-1-methyl-2-[1H-indole-4,7-dione]prop-2-en- 1-ol (EO9, NSC 382459) and their regioisomers as hypoxia-selective agents: structure-cytotoxicity in vitro.

Jaffar M, Naylor MA, Robertson N, Lockyer SD, Phillips RM, Everett SA, Adams GE, Stratford IJ. Jaffar M, et al. Among authors: stratford ij. Anticancer Drug Des. 1998 Mar;13(2):105-23. Anticancer Drug Des. 1998. PMID: 9524554

6

Indolequinone antitumor agents: reductive activation and elimination from (5-methoxy-1-methyl-4,7-dioxoindol-3-yl)methyl derivatives and hypoxia-selective cytotoxicity in vitro.

Naylor MA, Swann E, Everett SA, Jaffar M, Nolan J, Robertson N, Lockyer SD, Patel KB, Dennis MF, Stratford MR, Wardman P, Adams GE, Moody CJ, Stratford IJ. Naylor MA, et al. Among authors: stratford ij, stratford mr. J Med Chem. 1998 Jul 16;41(15):2720-31. doi: 10.1021/jm970744w. J Med Chem. 1998. PMID: 9667963

7

Targeting hypoxia with a new generation of indolequinones.

Jaffar M, Naylor MA, Robertson N, Stratford IJ. Jaffar M, et al. Among authors: stratford ij. Anticancer Drug Des. 1998 Sep;13(6):593-609. Anticancer Drug Des. 1998. PMID: 9755720 Review.

8

S-2-amino-5-azolylpentanoic acids related to L-ornithine as inhibitors of the isoforms of nitric oxide synthase (NOS).

Ulhaq S, Chinje EC, Naylor MA, Jaffar M, Stratford IJ, Threadgill MD. Ulhaq S, et al. Among authors: stratford ij. Bioorg Med Chem. 1998 Nov;6(11):2139-49. doi: 10.1016/s0968-0896(98)00174-6. Bioorg Med Chem. 1998. PMID: 9881104

9

Prodrugs for targeting hypoxic tissues: regiospecific elimination of aspirin from reduced indolequinones.

Jaffar M, Everett SA, Naylor MA, Moore SG, Ulhaq S, Patel KB, Stratford MR, Nolan J, Wardman P, Stratford IJ. Jaffar M, et al. Among authors: stratford ij, stratford mr. Bioorg Med Chem Lett. 1999 Jan 4;9(1):113-8. doi: 10.1016/s0960-894x(98)00695-7. Bioorg Med Chem Lett. 1999. PMID: 9990467

10

The relative importance of NADPH: cytochrome c (P450) reductase for determining the sensitivity of human tumour cells to the indolequinone EO9 and related analogues lacking functionality at the C-2 and C-3 positions.

Saunders MP, Jaffar M, Patterson AV, Nolan J, Naylor MA, Phillips RM, Harris AL, Stratford IJ. Saunders MP, et al. Among authors: stratford ij. Biochem Pharmacol. 2000 Apr 15;59(8):993-6. doi: 10.1016/s0006-2952(99)00405-0. Biochem Pharmacol. 2000. PMID: 10692564

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