Mirghani RA - Search Results

1

The roles of cytochrome P450 3A4 and 1A2 in the 3-hydroxylation of quinine in vivo.

Mirghani RA, Hellgren U, Westerberg PA, Ericsson O, Bertilsson L, Gustafsson LL. Mirghani RA, et al. Clin Pharmacol Ther. 1999 Nov;66(5):454-60. doi: 10.1016/S0009-9236(99)70008-1. Clin Pharmacol Ther. 1999. PMID: 10579472 Clinical Trial.

2

Enzyme kinetics for the formation of 3-hydroxyquinine and three new metabolites of quinine in vitro; 3-hydroxylation by CYP3A4 is indeed the major metabolic pathway.

Mirghani RA, Yasar U, Zheng T, Cook JM, Gustafsson LL, Tybring G, Ericsson O. Mirghani RA, et al. Drug Metab Dispos. 2002 Dec;30(12):1368-71. doi: 10.1124/dmd.30.12.1368. Drug Metab Dispos. 2002. PMID: 12433805

3

Quinine 3-hydroxylation as a biomarker reaction for the activity of CYP3A4 in man.

Mirghani RA, Ericsson O, Tybring G, Gustafsson LL, Bertilsson L. Mirghani RA, et al. Eur J Clin Pharmacol. 2003 May;59(1):23-8. doi: 10.1007/s00228-003-0575-5. Epub 2003 Mar 11. Eur J Clin Pharmacol. 2003. PMID: 12743670 Clinical Trial.

4

The Karolinska cocktail for phenotyping of five human cytochrome P450 enzymes.

Christensen M, Andersson K, Dalén P, Mirghani RA, Muirhead GJ, Nordmark A, Tybring G, Wahlberg A, Yaşar U, Bertilsson L. Christensen M, et al. Among authors: mirghani ra. Clin Pharmacol Ther. 2003 Jun;73(6):517-28. doi: 10.1016/S0009-9236(03)00050-X. Clin Pharmacol Ther. 2003. PMID: 12811361 Clinical Trial.

5

Metabolism and elimination of quinine in healthy volunteers.

Mirghani RA, Hellgren U, Bertilsson L, Gustafsson LL, Ericsson O. Mirghani RA, et al. Eur J Clin Pharmacol. 2003 Sep;59(5-6):423-7. doi: 10.1007/s00228-003-0637-8. Epub 2003 Aug 12. Eur J Clin Pharmacol. 2003. PMID: 12920491 Clinical Trial.

6

Alprazolam as a probe for CYP3A using a single blood sample: pharmacokinetics of parent drug, and of alpha- and 4-hydroxy metabolites in healthy subjects.

Wennerholm A, Allqvist A, Svensson JO, Gustafsson LL, Mirghani RA, Bertilsson L. Wennerholm A, et al. Among authors: mirghani ra. Eur J Clin Pharmacol. 2005 Apr;61(2):113-8. doi: 10.1007/s00228-004-0861-x. Epub 2005 Apr 2. Eur J Clin Pharmacol. 2005. PMID: 15806426 Clinical Trial.

7

Inhibition of CYP3A4 and CYP3A5 catalyzed metabolism of alprazolam and quinine by ketoconazole as racemate and four different enantiomers.

Allqvist A, Miura J, Bertilsson L, Mirghani RA. Allqvist A, et al. Among authors: mirghani ra. Eur J Clin Pharmacol. 2007 Feb;63(2):173-9. doi: 10.1007/s00228-006-0230-z. Epub 2007 Jan 3. Eur J Clin Pharmacol. 2007. PMID: 17200836

8

Effects of Plasmodium falciparum infection on the pharmacokinetics of quinine and its metabolites in pregnant and non-pregnant Sudanese women.

Mirghani RA, Elagib I, Elghazali G, Hellgren U, Gustafsson LL. Mirghani RA, et al. Eur J Clin Pharmacol. 2010 Dec;66(12):1229-34. doi: 10.1007/s00228-010-0877-3. Epub 2010 Aug 18. Eur J Clin Pharmacol. 2010. PMID: 20717655

9

High-performance liquid chromatographic method for the determination of the major quinine metabolite, 3-hydroxyquinine, in plasma and urine.

Mirghani RA, Ericsson O, Gustafsson LL. Mirghani RA, et al. J Chromatogr B Biomed Sci Appl. 1998 Apr 24;708(1-2):209-16. doi: 10.1016/s0378-4347(97)00629-4. J Chromatogr B Biomed Sci Appl. 1998. PMID: 9653964

10

Simultaneous determination of quinine and four metabolites in plasma and urine by high-performance liquid chromatography.

Mirghani RA, Ericsson O, Cook J, Yu P, Gustafsson LL. Mirghani RA, et al. J Chromatogr B Biomed Sci Appl. 2001 Apr 15;754(1):57-64. doi: 10.1016/s0378-4347(00)00577-6. J Chromatogr B Biomed Sci Appl. 2001. PMID: 11318427

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