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Discovery of a novel dopamine transporter inhibitor, 4-hydroxy-1-methyl-4-(4-methylphenyl)-3-piperidyl 4-methylphenyl ketone, as a potential cocaine antagonist through 3D-database pharmacophore searching. Molecular modeling, structure-activity relationships, and behavioral pharmacological studies.
Wang S, Sakamuri S, Enyedy IJ, Kozikowski AP, Deschaux O, Bandyopadhyay BC, Tella SR, Zaman WA, Johnson KM. Wang S, et al. Among authors: deschaux o. J Med Chem. 2000 Feb 10;43(3):351-60. doi: 10.1021/jm990516x. J Med Chem. 2000. PMID: 10669562
Mixed cocaine agonist/antagonist properties of (+)-methyl 4beta-(4-chlorophenyl)-1-methylpiperidine-3alpha-carboxylate, a piperidine-based analog of cocaine.
Kozikowski AP, Johnson KM, Deschaux O, Bandyopadhyay BC, Araldi GL, Carmona G, Munzar P, Smith MP, Balster RL, Beardsley PM, Tella SR. Kozikowski AP, et al. Among authors: deschaux o. J Pharmacol Exp Ther. 2003 Apr;305(1):143-50. doi: 10.1124/jpet.102.046318. J Pharmacol Exp Ther. 2003. PMID: 12649362
Hippocampal neurogenesis protects against cocaine-primed relapse.
Deschaux O, Vendruscolo LF, Schlosburg JE, Diaz-Aguilar L, Yuan CJ, Sobieraj JC, George O, Koob GF, Mandyam CD. Deschaux O, et al. Addict Biol. 2014 Jul;19(4):562-74. doi: 10.1111/adb.12019. Epub 2012 Dec 24. Addict Biol. 2014. PMID: 23278919 Free PMC article.
26 results