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Experimental closed head injury: analysis of neurological outcome, blood-brain barrier dysfunction, intracranial neutrophil infiltration, and neuronal cell death in mice deficient in genes for pro-inflammatory cytokines.
Stahel PF, Shohami E, Younis FM, Kariya K, Otto VI, Lenzlinger PM, Grosjean MB, Eugster HP, Trentz O, Kossmann T, Morganti-Kossmann MC. Stahel PF, et al. Among authors: younis fm. J Cereb Blood Flow Metab. 2000 Feb;20(2):369-80. doi: 10.1097/00004647-200002000-00019. J Cereb Blood Flow Metab. 2000. PMID: 10698075
A novel phospholipid derivative of indomethacin, DP-155 [mixture of 1-steroyl and 1-palmitoyl-2-{6-[1-(p-chlorobenzoyl)-5-methoxy-2-methyl-3-indolyl acetamido]hexanoyl}-sn-glycero-3-phosophatidyl [corrected] choline], shows superior safety and similar efficacy in reducing brain amyloid beta in an Alzheimer's disease model.
Dvir E, Friedman JE, Lee JY, Koh JY, Younis F, Raz S, Shapiro I, Hoffman A, Dahan A, Rosenberg G, Angel I, Kozak A, Duvdevani R. Dvir E, et al. J Pharmacol Exp Ther. 2006 Sep;318(3):1248-56. doi: 10.1124/jpet.106.103184. Epub 2006 Jun 8. J Pharmacol Exp Ther. 2006. PMID: 16763096
15 results