Pakusch M - Search Results

1

Identification of DIABLO, a mammalian protein that promotes apoptosis by binding to and antagonizing IAP proteins.

Verhagen AM, Ekert PG, Pakusch M, Silke J, Connolly LM, Reid GE, Moritz RL, Simpson RJ, Vaux DL. Verhagen AM, et al. Among authors: pakusch m. Cell. 2000 Jul 7;102(1):43-53. doi: 10.1016/s0092-8674(00)00009-x. Cell. 2000. PMID: 10929712 Free article.

2

HtrA2 promotes cell death through its serine protease activity and its ability to antagonize inhibitor of apoptosis proteins.

Verhagen AM, Silke J, Ekert PG, Pakusch M, Kaufmann H, Connolly LM, Day CL, Tikoo A, Burke R, Wrobel C, Moritz RL, Simpson RJ, Vaux DL. Verhagen AM, et al. Among authors: pakusch m. J Biol Chem. 2002 Jan 4;277(1):445-54. doi: 10.1074/jbc.M109891200. Epub 2001 Oct 16. J Biol Chem. 2002. PMID: 11604410 Free article.

3

The anti-apoptotic activity of XIAP is retained upon mutation of both the caspase 3- and caspase 9-interacting sites.

Silke J, Hawkins CJ, Ekert PG, Chew J, Day CL, Pakusch M, Verhagen AM, Vaux DL. Silke J, et al. Among authors: pakusch m. J Cell Biol. 2002 Apr 1;157(1):115-24. doi: 10.1083/jcb.200108085. Epub 2002 Apr 1. J Cell Biol. 2002. PMID: 11927604 Free PMC article.

4

Unlike Diablo/smac, Grim promotes global ubiquitination and specific degradation of X chromosome-linked inhibitor of apoptosis (XIAP) and neither cause apoptosis.

Silke J, Kratina T, Ekert PG, Pakusch M, Vaux DL. Silke J, et al. Among authors: pakusch m. J Biol Chem. 2004 Feb 6;279(6):4313-21. doi: 10.1074/jbc.M305661200. Epub 2003 Oct 21. J Biol Chem. 2004. PMID: 14570909 Free article.

5

Determination of cell survival by RING-mediated regulation of inhibitor of apoptosis (IAP) protein abundance.

Silke J, Kratina T, Chu D, Ekert PG, Day CL, Pakusch M, Huang DC, Vaux DL. Silke J, et al. Among authors: pakusch m. Proc Natl Acad Sci U S A. 2005 Nov 8;102(45):16182-7. doi: 10.1073/pnas.0502828102. Epub 2005 Nov 1. Proc Natl Acad Sci U S A. 2005. PMID: 16263936 Free PMC article.

6

Direct inhibition of caspase 3 is dispensable for the anti-apoptotic activity of XIAP.

Silke J, Ekert PG, Day CL, Hawkins CJ, Baca M, Chew J, Pakusch M, Verhagen AM, Vaux DL. Silke J, et al. Among authors: pakusch m. EMBO J. 2001 Jun 15;20(12):3114-23. doi: 10.1093/emboj/20.12.3114. EMBO J. 2001. PMID: 11406588 Free PMC article.

7

Tissue distribution of Diablo/Smac revealed by monoclonal antibodies.

Tikoo A, O'Reilly L, Day CL, Verhagen AM, Pakusch M, Vaux DL. Tikoo A, et al. Among authors: pakusch m. Cell Death Differ. 2002 Jul;9(7):710-6. doi: 10.1038/sj.cdd.4401031. Cell Death Differ. 2002. PMID: 12058276

8

Cloning and expression of apoptosis inhibitory protein homologs that function to inhibit apoptosis and/or bind tumor necrosis factor receptor-associated factors.

Uren AG, Pakusch M, Hawkins CJ, Puls KL, Vaux DL. Uren AG, et al. Among authors: pakusch m. Proc Natl Acad Sci U S A. 1996 May 14;93(10):4974-8. doi: 10.1073/pnas.93.10.4974. Proc Natl Acad Sci U S A. 1996. PMID: 8643514 Free PMC article.

9

Survivin and the inner centromere protein INCENP show similar cell-cycle localization and gene knockout phenotype.

Uren AG, Wong L, Pakusch M, Fowler KJ, Burrows FJ, Vaux DL, Choo KH. Uren AG, et al. Among authors: pakusch m. Curr Biol. 2000 Nov 2;10(21):1319-28. doi: 10.1016/s0960-9822(00)00769-7. Curr Biol. 2000. PMID: 11084331 Free article.

10

Caspase-2 is not required for thymocyte or neuronal apoptosis even though cleavage of caspase-2 is dependent on both Apaf-1 and caspase-9.

O'Reilly LA, Ekert P, Harvey N, Marsden V, Cullen L, Vaux DL, Hacker G, Magnusson C, Pakusch M, Cecconi F, Kuida K, Strasser A, Huang DC, Kumar S. O'Reilly LA, et al. Among authors: pakusch m. Cell Death Differ. 2002 Aug;9(8):832-41. doi: 10.1038/sj.cdd.4401033. Cell Death Differ. 2002. PMID: 12107826

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