Kulkarni RN - Search Results

1

Loss of insulin signaling in hepatocytes leads to severe insulin resistance and progressive hepatic dysfunction.

Michael MD, Kulkarni RN, Postic C, Previs SF, Shulman GI, Magnuson MA, Kahn CR. Michael MD, et al. Among authors: kulkarni rn. Mol Cell. 2000 Jul;6(1):87-97. Mol Cell. 2000. PMID: 10949030 Free article.

2

Tissue-specific knockout of the insulin receptor in pancreatic beta cells creates an insulin secretory defect similar to that in type 2 diabetes.

Kulkarni RN, Brüning JC, Winnay JN, Postic C, Magnuson MA, Kahn CR. Kulkarni RN, et al. Cell. 1999 Feb 5;96(3):329-39. doi: 10.1016/s0092-8674(00)80546-2. Cell. 1999. PMID: 10025399 Free article.

3

Altered function of insulin receptor substrate-1-deficient mouse islets and cultured beta-cell lines.

Kulkarni RN, Winnay JN, Daniels M, Brüning JC, Flier SN, Hanahan D, Kahn CR. Kulkarni RN, et al. J Clin Invest. 1999 Dec;104(12):R69-75. doi: 10.1172/JCI8339. J Clin Invest. 1999. PMID: 10606633 Free PMC article.

4

Roles of insulin receptor substrate-1, phosphatidylinositol 3-kinase, and release of intracellular Ca2+ stores in insulin-stimulated insulin secretion in beta -cells.

Aspinwall CA, Qian WJ, Roper MG, Kulkarni RN, Kahn CR, Kennedy RT. Aspinwall CA, et al. Among authors: kulkarni rn. J Biol Chem. 2000 Jul 21;275(29):22331-8. doi: 10.1074/jbc.M909647199. J Biol Chem. 2000. PMID: 10764813 Free article.

5

A model to explore the interaction between muscle insulin resistance and beta-cell dysfunction in the development of type 2 diabetes.

Mauvais-Jarvis F, Virkamaki A, Michael MD, Winnay JN, Zisman A, Kulkarni RN, Kahn CR. Mauvais-Jarvis F, et al. Among authors: kulkarni rn. Diabetes. 2000 Dec;49(12):2126-34. doi: 10.2337/diabetes.49.12.2126. Diabetes. 2000. PMID: 11118016

6

Knockout mice challenge our concepts of glucose homeostasis and the pathogenesis of diabetes mellitus.

Kahn CR, Brüning JC, Michael MD, Kulkarni RN. Kahn CR, et al. Among authors: kulkarni rn. J Pediatr Endocrinol Metab. 2000;13 Suppl 6:1377-84. doi: 10.1515/jpem-2000-s611. J Pediatr Endocrinol Metab. 2000. PMID: 11202213 Review.

7

Evidence for a circulating islet cell growth factor in insulin-resistant states.

Flier SN, Kulkarni RN, Kahn CR. Flier SN, et al. Among authors: kulkarni rn. Proc Natl Acad Sci U S A. 2001 Jun 19;98(13):7475-80. doi: 10.1073/pnas.131192998. Epub 2001 Jun 12. Proc Natl Acad Sci U S A. 2001. PMID: 11404474 Free PMC article.

8

Selective insulin signaling through A and B insulin receptors regulates transcription of insulin and glucokinase genes in pancreatic beta cells.

Leibiger B, Leibiger IB, Moede T, Kemper S, Kulkarni RN, Kahn CR, de Vargas LM, Berggren PO. Leibiger B, et al. Among authors: kulkarni rn. Mol Cell. 2001 Mar;7(3):559-70. doi: 10.1016/s1097-2765(01)00203-9. Mol Cell. 2001. PMID: 11463381 Free article.

9

Effect of the insulin mimetic L-783,281 on intracellular Ca2+ and insulin secretion from pancreatic beta-cells.

Roper MG, Qian WJ, Zhang BB, Kulkarni RN, Kahn CR, Kennedy RT. Roper MG, et al. Among authors: kulkarni rn. Diabetes. 2002 Feb;51 Suppl 1:S43-9. doi: 10.2337/diabetes.51.2007.s43. Diabetes. 2002. PMID: 11815457

10

beta-cell-specific deletion of the Igf1 receptor leads to hyperinsulinemia and glucose intolerance but does not alter beta-cell mass.

Kulkarni RN, Holzenberger M, Shih DQ, Ozcan U, Stoffel M, Magnuson MA, Kahn CR. Kulkarni RN, et al. Nat Genet. 2002 May;31(1):111-5. doi: 10.1038/ng872. Epub 2002 Apr 1. Nat Genet. 2002. PMID: 11923875

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