Thurston DE - Search Results

1

Effect of C2-exo unsaturation on the cytotoxicity and DNA-binding reactivity of pyrrolo[2,1-c][1,4]benzodiazepines.

Gregson SJ, Howard PW, Corcoran KE, Barcella S, Yasin MM, Hurst AA, Jenkins TC, Kelland LR, Thurston DE. Gregson SJ, et al. Among authors: thurston de. Bioorg Med Chem Lett. 2000 Aug 21;10(16):1845-7. doi: 10.1016/s0960-894x(00)00351-6. Bioorg Med Chem Lett. 2000. PMID: 10969982

2

Synthesis and biological evaluation of an N10-Psec substituted pyrrolo[2,1-c][1,4]benzodiazepine prodrug.

Berry JM, Howard PW, Kelland LR, Thurston DE. Berry JM, et al. Among authors: thurston de. Bioorg Med Chem Lett. 2002 May 20;12(10):1413-6. doi: 10.1016/s0960-894x(02)00150-6. Bioorg Med Chem Lett. 2002. PMID: 11992788

3

Synthesis of the first examples of A-C8/C-C2 amide-Linked pyrrolo[2,1-c][1,4]benzodiazepine dimers.

Gregson SJ, Howard PW, Thurston DE. Gregson SJ, et al. Among authors: thurston de. Bioorg Med Chem Lett. 2003 Jul 21;13(14):2277-80. doi: 10.1016/s0960-894x(03)00436-0. Bioorg Med Chem Lett. 2003. PMID: 12824017

4

Synthesis of a novel C2-aryl substituted 1,2-unsaturated pyrrolobenzodiazepine.

Kang GD, Howard PW, Thurston DE. Kang GD, et al. Among authors: thurston de. Chem Commun (Camb). 2003 Jul 21;(14):1688-9. doi: 10.1039/b303274d. Chem Commun (Camb). 2003. PMID: 12877504

5

Linker length modulates DNA cross-linking reactivity and cytotoxic potency of C8/C8' ether-linked C2-exo-unsaturated pyrrolo[2,1-c][1,4]benzodiazepine (PBD) dimers.

Gregson SJ, Howard PW, Gullick DR, Hamaguchi A, Corcoran KE, Brooks NA, Hartley JA, Jenkins TC, Patel S, Guille MJ, Thurston DE. Gregson SJ, et al. Among authors: thurston de. J Med Chem. 2004 Feb 26;47(5):1161-74. doi: 10.1021/jm030897l. J Med Chem. 2004. PMID: 14971896

6

A novel approach to the synthesis of cytotoxic C2-C3 unsaturated pyrrolo[2,1-c]benzodiazepines (PBDs) with conjugated acrylyl C2-substituents.

Chen Z, Gregson SJ, Howard PW, Thurston DE. Chen Z, et al. Among authors: thurston de. Bioorg Med Chem Lett. 2004 Mar 22;14(6):1547-9. doi: 10.1016/j.bmcl.2003.12.094. Bioorg Med Chem Lett. 2004. PMID: 15006400

7

Synthesis and biological evaluation of pyrrolo[2,1-c][1,4]benzodiazepine (PBD) C8 cyclic amine conjugates.

Masterson LA, Croker SJ, Jenkins TC, Howard PW, Thurston DE. Masterson LA, et al. Among authors: thurston de. Bioorg Med Chem Lett. 2004 Feb 23;14(4):901-4. doi: 10.1016/j.bmcl.2003.12.017. Bioorg Med Chem Lett. 2004. PMID: 15012990

8

Application of the Stille coupling reaction to the synthesis of C2-substituted endo-exo unsaturated pyrrolo[2,1-c][1,4]benzodiazepines (PBDs).

Tiberghien AC, Hagan D, Howard PW, Thurston DE. Tiberghien AC, et al. Among authors: thurston de. Bioorg Med Chem Lett. 2004 Oct 18;14(20):5041-4. doi: 10.1016/j.bmcl.2004.08.002. Bioorg Med Chem Lett. 2004. PMID: 15380195

9

Synthesis and biological evaluation of novel pyrrolo[2,1-c][1,4]benzodiazepine prodrugs for use in antibody-directed enzyme prodrug therapy.

Masterson LA, Spanswick VJ, Hartley JA, Begent RH, Howard PW, Thurston DE. Masterson LA, et al. Among authors: thurston de. Bioorg Med Chem Lett. 2006 Jan 15;16(2):252-6. doi: 10.1016/j.bmcl.2005.10.017. Epub 2005 Nov 15. Bioorg Med Chem Lett. 2006. PMID: 16290933

10

Design, synthesis, and biophysical and biological evaluation of a series of pyrrolobenzodiazepine-poly(N-methylpyrrole) conjugates.

Wells G, Martin CR, Howard PW, Sands ZA, Laughton CA, Tiberghien A, Woo CK, Masterson LA, Stephenson MJ, Hartley JA, Jenkins TC, Shnyder SD, Loadman PM, Waring MJ, Thurston DE. Wells G, et al. Among authors: thurston de. J Med Chem. 2006 Sep 7;49(18):5442-61. doi: 10.1021/jm051199z. J Med Chem. 2006. PMID: 16942018

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