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Immunohistochemical determination of p53 protein does not predict clinical response in advanced colorectal cancer with low thymidylate synthase expression receiving a bolus 5-fluorouracil-leucovorin combination.
Cascinu S, Catalano V, Aschele C, Barni S, Debernardis D, Gallo L, Bandelloni R, Staccioli MP, Baldelli AM, Brenna A, Valenti A, Muretto P, Catalano G. Cascinu S, et al. Among authors: debernardis d. Ann Oncol. 2000 Aug;11(8):1053-6. doi: 10.1023/a:1008362511552. Ann Oncol. 2000. PMID: 11038045 Free article. Clinical Trial.
Thymidylate synthase protein expression in colorectal cancer metastases predicts for clinical outcome to leucovorin-modulated bolus or infusional 5-fluorouracil but not methotrexate-modulated bolus 5-fluorouracil.
Aschele C, Debernardis D, Bandelloni R, Cascinu S, Catalano V, Giordani P, Barni S, Turci D, Drudi G, Lonardi S, Gallo L, Maley F, Monfardini S. Aschele C, et al. Among authors: debernardis d. Ann Oncol. 2002 Dec;13(12):1882-92. doi: 10.1093/annonc/mdf327. Ann Oncol. 2002. PMID: 12453856 Free article.
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