Takaki Y - Search Results

1

Biochemical identification of the neutral endopeptidase family member responsible for the catabolism of amyloid beta peptide in the brain.

Takaki Y, Iwata N, Tsubuki S, Taniguchi S, Toyoshima S, Lu B, Gerard NP, Gerard C, Lee HJ, Shirotani K, Saido TC. Takaki Y, et al. J Biochem. 2000 Dec;128(6):897-902. doi: 10.1093/oxfordjournals.jbchem.a022839. J Biochem. 2000. PMID: 11098130 Free article.

2

Region-specific reduction of A beta-degrading endopeptidase, neprilysin, in mouse hippocampus upon aging.

Iwata N, Takaki Y, Fukami S, Tsubuki S, Saido TC. Iwata N, et al. Among authors: takaki y. J Neurosci Res. 2002 Nov 1;70(3):493-500. doi: 10.1002/jnr.10390. J Neurosci Res. 2002. PMID: 12391610

3

Dutch, Flemish, Italian, and Arctic mutations of APP and resistance of Abeta to physiologically relevant proteolytic degradation.

Tsubuki S, Takaki Y, Saido TC. Tsubuki S, et al. Among authors: takaki y. Lancet. 2003 Jun 7;361(9373):1957-8. doi: 10.1016/s0140-6736(03)13555-6. Lancet. 2003. PMID: 12801742

4

Alzheimer's disease, neuropeptides, neuropeptidase, and amyloid-beta peptide metabolism.

Saito T, Takaki Y, Iwata N, Trojanowski J, Saido TC. Saito T, et al. Among authors: takaki y. Sci Aging Knowledge Environ. 2003 Jan 22;2003(3):PE1. doi: 10.1126/sageke.2003.3.pe1. Sci Aging Knowledge Environ. 2003. PMID: 12844556 Review.

5

Presynaptic localization of neprilysin contributes to efficient clearance of amyloid-beta peptide in mouse brain.

Iwata N, Mizukami H, Shirotani K, Takaki Y, Muramatsu S, Lu B, Gerard NP, Gerard C, Ozawa K, Saido TC. Iwata N, et al. Among authors: takaki y. J Neurosci. 2004 Jan 28;24(4):991-8. doi: 10.1523/JNEUROSCI.4792-03.2004. J Neurosci. 2004. PMID: 14749444 Free PMC article.

6

Somatostatin regulates brain amyloid beta peptide Abeta42 through modulation of proteolytic degradation.

Saito T, Iwata N, Tsubuki S, Takaki Y, Takano J, Huang SM, Suemoto T, Higuchi M, Saido TC. Saito T, et al. Among authors: takaki y. Nat Med. 2005 Apr;11(4):434-9. doi: 10.1038/nm1206. Epub 2005 Mar 20. Nat Med. 2005. PMID: 15778722

7

Identification of the major Abeta1-42-degrading catabolic pathway in brain parenchyma: suppression leads to biochemical and pathological deposition.

Iwata N, Tsubuki S, Takaki Y, Watanabe K, Sekiguchi M, Hosoki E, Kawashima-Morishima M, Lee HJ, Hama E, Sekine-Aizawa Y, Saido TC. Iwata N, et al. Among authors: takaki y. Nat Med. 2000 Feb;6(2):143-50. doi: 10.1038/72237. Nat Med. 2000. PMID: 10655101

8

Neprilysin degrades both amyloid beta peptides 1-40 and 1-42 most rapidly and efficiently among thiorphan- and phosphoramidon-sensitive endopeptidases.

Shirotani K, Tsubuki S, Iwata N, Takaki Y, Harigaya W, Maruyama K, Kiryu-Seo S, Kiyama H, Iwata H, Tomita T, Iwatsubo T, Saido TC. Shirotani K, et al. Among authors: takaki y. J Biol Chem. 2001 Jun 15;276(24):21895-901. doi: 10.1074/jbc.M008511200. Epub 2001 Mar 6. J Biol Chem. 2001. PMID: 11278416 Free article.

9

Metabolic regulation of brain Abeta by neprilysin.

Iwata N, Tsubuki S, Takaki Y, Shirotani K, Lu B, Gerard NP, Gerard C, Hama E, Lee HJ, Saido TC. Iwata N, et al. Among authors: takaki y. Science. 2001 May 25;292(5521):1550-2. doi: 10.1126/science.1059946. Science. 2001. PMID: 11375493

10

Molecular cloning and expression of aminopeptidase A isoforms from rat hippocampus.

Lee HJ, Tomioka M, Takaki Y, Masumoto H, Saido TC. Lee HJ, et al. Among authors: takaki y. Biochim Biophys Acta. 2000 Sep 7;1493(1-2):273-8. doi: 10.1016/s0167-4781(00)00183-4. Biochim Biophys Acta. 2000. PMID: 10978538

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