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Hexokinases inhibit death receptor-dependent apoptosis on the mitochondria.
Lauterwasser J, Fimm-Todt F, Oelgeklaus A, Schreiner A, Funk K, Falquez-Medina H, Klesse R, Jahreis G, Zerbes RM, O'Neill K, van der Laan M, Luo X, Edlich F. Lauterwasser J, et al. Among authors: luo x. Proc Natl Acad Sci U S A. 2021 Aug 17;118(33):e2021175118. doi: 10.1073/pnas.2021175118. Proc Natl Acad Sci U S A. 2021. PMID: 34385311 Free PMC article.
BH3-only proteins target BCL-xL/MCL-1, not BAX/BAK, to initiate apoptosis.
Huang K, O'Neill KL, Li J, Zhou W, Han N, Pang X, Wu W, Struble L, Borgstahl G, Liu Z, Zhang L, Luo X. Huang K, et al. Among authors: luo x. Cell Res. 2019 Nov;29(11):942-952. doi: 10.1038/s41422-019-0231-y. Epub 2019 Sep 24. Cell Res. 2019. PMID: 31551537 Free PMC article.
Active Bax and Bak are functional holins.
Pang X, Moussa SH, Targy NM, Bose JL, George NM, Gries C, Lopez H, Zhang L, Bayles KW, Young R, Luo X. Pang X, et al. Among authors: luo x. Genes Dev. 2011 Nov 1;25(21):2278-90. doi: 10.1101/gad.171645.111. Epub 2011 Oct 17. Genes Dev. 2011. PMID: 22006182 Free PMC article.
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