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New 3-[4-(aryl)piperazin-1-yl]-1-(benzo[b]thiophen-3-yl)propane derivatives with dual action at 5-HT1A serotonin receptors and serotonin transporter as a new class of antidepressants.
Martínez J, Pérez S, Oficialdegui AM, Heras B, Orús L, Villanueva H, Palop JA, Roca J, Mourelle M, Bosch A, Del Castillo JC, Lasheras B, Tordera R, del Río J, Monge A. Martínez J, et al. Among authors: tordera r. Eur J Med Chem. 2001 Jan;36(1):55-61. doi: 10.1016/s0223-5234(00)01198-3. Eur J Med Chem. 2001. PMID: 11231049
Design, synthesis and biological evaluation of new 3-[(4-aryl)piperazin-1-yl]-1-arylpropane derivatives as potential antidepressants with a dual mode of action: serotonin reuptake inhibition and 5-HT1A receptor antagonism.
Oficialdegui AM, Martinez J, Pérez S, Heras B, Irurzun M, Palop JA, Tordera R, Lasheras B, del Río J, Monge A. Oficialdegui AM, et al. Among authors: tordera r. Farmaco. 2000 May;55(5):345-53. doi: 10.1016/s0014-827x(00)00050-1. Farmaco. 2000. PMID: 10983279
New 1-aryl-3-(4-arylpiperazin-1-yl)propane derivatives, with dual action at 5-HT1A serotonin receptors and serotonin transporter, as a new class of antidepressants.
Martínez-Esparza J, Oficialdegui AM, Pérez-Silanes S, Heras B, Orús L, Palop JA, Lasheras B, Roca J, Mourelle M, Bosch A, Del Castillo JC, Tordera R, Del Río J, Monge A. Martínez-Esparza J, et al. Among authors: tordera r. J Med Chem. 2001 Feb 1;44(3):418-28. doi: 10.1021/jm001059j. J Med Chem. 2001. PMID: 11462981
Synthesis and molecular modeling of new 1-aryl-3-[4-arylpiperazin-1-yl]-1-propane derivatives with high affinity at the serotonin transporter and at 5-HT(1A) receptors.
Orús L, Pérez-Silanes S, Oficialdegui AM, Martínez-Esparza J, Del Castillo JC, Mourelle M, Langer T, Guccione S, Donzella G, Krovat EM, Poptodorov K, Lasheras B, Ballaz S, Hervías I, Tordera R, Del Río J, Monge A. Orús L, et al. Among authors: tordera r. J Med Chem. 2002 Sep 12;45(19):4128-39. doi: 10.1021/jm0111200. J Med Chem. 2002. PMID: 12213056
48 results