Shakkottai VG - Search Results

1

Design and characterization of a highly selective peptide inhibitor of the small conductance calcium-activated K+ channel, SkCa2.

Shakkottai VG, Regaya I, Wulff H, Fajloun Z, Tomita H, Fathallah M, Cahalan MD, Gargus JJ, Sabatier JM, Chandy KG. Shakkottai VG, et al. J Biol Chem. 2001 Nov 16;276(46):43145-51. doi: 10.1074/jbc.M106981200. Epub 2001 Aug 29. J Biol Chem. 2001. PMID: 11527975 Free article.

2

SK3-1C, a dominant-negative suppressor of SKCa and IKCa channels.

Kolski-Andreaco A, Tomita H, Shakkottai VG, Gutman GA, Cahalan MD, Gargus JJ, Chandy KG. Kolski-Andreaco A, et al. Among authors: shakkottai vg. J Biol Chem. 2004 Feb 20;279(8):6893-904. doi: 10.1074/jbc.M311725200. Epub 2003 Nov 24. J Biol Chem. 2004. PMID: 14638680 Free article.

3

Novel truncated isoform of SK3 potassium channel is a potent dominant-negative regulator of SK currents: implications in schizophrenia.

Tomita H, Shakkottai VG, Gutman GA, Sun G, Bunney WE, Cahalan MD, Chandy KG, Gargus JJ. Tomita H, et al. Among authors: shakkottai vg. Mol Psychiatry. 2003 May;8(5):524-35, 460. doi: 10.1038/sj.mp.4001271. Mol Psychiatry. 2003. PMID: 12808432

4

Modulators of small- and intermediate-conductance calcium-activated potassium channels and their therapeutic indications.

Wulff H, Kolski-Andreaco A, Sankaranarayanan A, Sabatier JM, Shakkottai V. Wulff H, et al. Curr Med Chem. 2007;14(13):1437-57. doi: 10.2174/092986707780831186. Curr Med Chem. 2007. PMID: 17584055 Review.

5

Genomic organization and promoter analysis of human KCNN3 gene.

Sun G, Tomita H, Shakkottai VG, Gargus JJ. Sun G, et al. Among authors: shakkottai vg. J Hum Genet. 2001;46(8):463-70. doi: 10.1007/s100380170046. J Hum Genet. 2001. PMID: 11501944

6

Enhanced neuronal excitability in the absence of neurodegeneration induces cerebellar ataxia.

Shakkottai VG, Chou CH, Oddo S, Sailer CA, Knaus HG, Gutman GA, Barish ME, LaFerla FM, Chandy KG. Shakkottai VG, et al. J Clin Invest. 2004 Feb;113(4):582-90. doi: 10.1172/JCI20216. J Clin Invest. 2004. PMID: 14966567 Free PMC article.

7

SKCa channels mediate the medium but not the slow calcium-activated afterhyperpolarization in cortical neurons.

Villalobos C, Shakkottai VG, Chandy KG, Michelhaugh SK, Andrade R. Villalobos C, et al. Among authors: shakkottai vg. J Neurosci. 2004 Apr 7;24(14):3537-42. doi: 10.1523/JNEUROSCI.0380-04.2004. J Neurosci. 2004. PMID: 15071101 Free PMC article.

8

Discovery of Novel Activators of Large-Conductance Calcium-Activated Potassium Channels for the Treatment of Cerebellar Ataxia.

Srinivasan SR, Huang H, Chang WC, Nasburg JA, Nguyen HM, Strassmaier T, Wulff H, Shakkottai VG. Srinivasan SR, et al. Among authors: shakkottai vg. Mol Pharmacol. 2022 Jul;102(1):438-449. doi: 10.1124/molpharm.121.000478. Epub 2022 Apr 30. Mol Pharmacol. 2022. PMID: 35489717 Free PMC article.

9

Targeting potassium channels to treat cerebellar ataxia.

Bushart DD, Chopra R, Singh V, Murphy GG, Wulff H, Shakkottai VG. Bushart DD, et al. Among authors: shakkottai vg. Ann Clin Transl Neurol. 2018 Jan 22;5(3):297-314. doi: 10.1002/acn3.527. eCollection 2018 Mar. Ann Clin Transl Neurol. 2018. PMID: 29560375 Free PMC article.

10

Early changes in cerebellar physiology accompany motor dysfunction in the polyglutamine disease spinocerebellar ataxia type 3.

Shakkottai VG, do Carmo Costa M, Dell'Orco JM, Sankaranarayanan A, Wulff H, Paulson HL. Shakkottai VG, et al. J Neurosci. 2011 Sep 7;31(36):13002-14. doi: 10.1523/JNEUROSCI.2789-11.2011. J Neurosci. 2011. PMID: 21900579 Free PMC article.

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