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Page 1
S-palmitoylation of gamma-secretase subunits nicastrin and APH-1.
Cheng H, Vetrivel KS, Drisdel RC, Meckler X, Gong P, Leem JY, Li T, Carter M, Chen Y, Nguyen P, Iwatsubo T, Tomita T, Wong PC, Green WN, Kounnas MZ, Thinakaran G. Cheng H, et al. Among authors: leem jy. J Biol Chem. 2009 Jan 16;284(3):1373-84. doi: 10.1074/jbc.M806380200. Epub 2008 Nov 20. J Biol Chem. 2009. PMID: 19028695 Free PMC article.
The nonconserved hydrophilic loop domain of presenilin (PS) is not required for PS endoproteolysis or enhanced abeta 42 production mediated by familial early onset Alzheimer's disease-linked PS variants.
Saura CA, Tomita T, Soriano S, Takahashi M, Leem JY, Honda T, Koo EH, Iwatsubo T, Thinakaran G. Saura CA, et al. Among authors: leem jy. J Biol Chem. 2000 Jun 2;275(22):17136-42. doi: 10.1074/jbc.M909624199. J Biol Chem. 2000. PMID: 10748144 Free article.
Synthesis, in vitro assay, and molecular modeling of new piperidine derivatives having dual inhibitory potency against acetylcholinesterase and Abeta1-42 aggregation for Alzheimer's disease therapeutics.
Kwon YE, Park JY, No KT, Shin JH, Lee SK, Eun JS, Yang JH, Shin TY, Kim DK, Chae BS, Leem JY, Kim KH. Kwon YE, et al. Among authors: leem jy. Bioorg Med Chem. 2007 Oct 15;15(20):6596-607. doi: 10.1016/j.bmc.2007.07.003. Epub 2007 Jul 25. Bioorg Med Chem. 2007. PMID: 17681794
Inhibition of β-site amyloid precursor protein cleaving enzyme 1 and cholinesterases by pterosins via a specific structure-activity relationship with a strong BBB permeability.
Jannat S, Balupuri A, Ali MY, Hong SS, Choi CW, Choi YH, Ku JM, Kim WJ, Leem JY, Kim JE, Shrestha AC, Ham HN, Lee KH, Kim DM, Kang NS, Park GH. Jannat S, et al. Among authors: leem jy. Exp Mol Med. 2019 Feb 12;51(2):1-18. doi: 10.1038/s12276-019-0205-7. Exp Mol Med. 2019. PMID: 30755593 Free PMC article.
54 results