Levy MA - Search Results

1

SB-239063, a potent and selective inhibitor of p38 map kinase: preclinical pharmacokinetics and species-specific reversible isomerization.

Ward KW, Proksch JW, Azzarano LM, Salyers KL, McSurdy-Freed JE, Molnar TM, Levy MA, Smith BR. Ward KW, et al. Among authors: levy ma. Pharm Res. 2001 Sep;18(9):1336-44. doi: 10.1023/a:1013002414678. Pharm Res. 2001. PMID: 11683250

2

Development of an in vivo preclinical screen model to estimate absorption and bioavailability of xenobiotics.

Ward KW, Proksch JW, Levy MA, Smith BR. Ward KW, et al. Among authors: levy ma. Drug Metab Dispos. 2001 Jan;29(1):82-8. Drug Metab Dispos. 2001. PMID: 11124234

3

Preclinical pharmacokinetics of SB-203580, a potent inhibitor of p38 mitogen-activated protein kinase.

Ward KW, Prokscht JW, Azzaranot LM, Mumawa JA, Roethke TJ, Stelman GJ, Walsh MJ, Zeigler KS, McSurdy-Freed JE, Kehlert JR, Chokshi J, Levy MA, Smith BR. Ward KW, et al. Among authors: levy ma. Xenobiotica. 2001 Nov;31(11):783-97. doi: 10.1080/00498250110065621. Xenobiotica. 2001. PMID: 11765141

4

SB-242235, a selective inhibitor of p38 mitogen-activated protein kinase. I: preclinical pharmacokinetics.

Ward KW, Proksch JW, Salyers KL, Azzarano LM, Morgan JA, Roethke TJ, McSurdy-Freed JE, Levy MA, Smith BR. Ward KW, et al. Among authors: levy ma. Xenobiotica. 2002 Mar;32(3):221-33. doi: 10.1080/00498250110100720. Xenobiotica. 2002. PMID: 11958561 Clinical Trial.

5

SB-242235, a selective inhibitor of p38 mitogen-activated protein kinase. II: in vitro and in vivo metabolism studies and pharmacokinetic extrapolation to man.

Ward KW, Proksch JW, Gorycki PD, Yu CP, Ho MY, Bush BD, Levy MA, Smith BR. Ward KW, et al. Among authors: levy ma. Xenobiotica. 2002 Mar;32(3):235-50. doi: 10.1080/00498250110100711. Xenobiotica. 2002. PMID: 11958562

6

Evaluation of the use of accelerated infusions for the determination of pharmacokinetic linearity.

Ward KW, Griffiths R, Levy MA, Smith BR. Ward KW, et al. Among authors: levy ma. J Pharmacol Exp Ther. 2000 May;293(2):468-79. J Pharmacol Exp Ther. 2000. PMID: 10773017

7

Enhancement of in vitro and in vivo microdialysis recovery of SB-265123 using Intralipid and Encapsin as perfusates.

Ward KW, Medina SJ, Portelli ST, Mahar Doan KM, Spengler MD, Ben MM, Lundberg D, Levy MA, Chen EP. Ward KW, et al. Among authors: levy ma. Biopharm Drug Dispos. 2003 Jan;24(1):17-25. doi: 10.1002/bdd.332. Biopharm Drug Dispos. 2003. PMID: 12516075

8

Design of potent and selective human cathepsin K inhibitors that span the active site.

Thompson SK, Halbert SM, Bossard MJ, Tomaszek TA, Levy MA, Zhao B, Smith WW, Abdel-Meguid SS, Janson CA, D'Alessio KJ, McQueney MS, Amegadzie BY, Hanning CR, DesJarlais RL, Briand J, Sarkar SK, Huddleston MJ, Ijames CF, Carr SA, Garnes KT, Shu A, Heys JR, Bradbeer J, Zembryki D, Lee-Rykaczewski L, James IE, Lark MW, Drake FH, Gowen M, Gleason JG, Veber DF. Thompson SK, et al. Among authors: levy ma. Proc Natl Acad Sci U S A. 1997 Dec 23;94(26):14249-54. doi: 10.1073/pnas.94.26.14249. Proc Natl Acad Sci U S A. 1997. PMID: 9405598 Free PMC article.

9

Potent and selective nonpeptide inhibitors of caspases 3 and 7.

Lee D, Long SA, Murray JH, Adams JL, Nuttall ME, Nadeau DP, Kikly K, Winkler JD, Sung CM, Ryan MD, Levy MA, Keller PM, DeWolf WE Jr. Lee D, et al. Among authors: levy ma. J Med Chem. 2001 Jun 7;44(12):2015-26. doi: 10.1021/jm0100537. J Med Chem. 2001. PMID: 11384246

10

Cloning, expression and functional characterization of type 1 and type 2 steroid 5 alpha-reductases from Cynomolgus monkey: comparisons with human and rat isoenzymes.

Levy MA, Brandt M, Sheedy KM, Holt DA, Heaslip JI, Trill JJ, Ryan PJ, Morris RA, Garrison LM, Bergsma DJ. Levy MA, et al. J Steroid Biochem Mol Biol. 1995 Apr;52(4):307-19. doi: 10.1016/0960-0760(94)00183-m. J Steroid Biochem Mol Biol. 1995. PMID: 7734398

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