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The inhibitory receptor FcgammaRII reduces joint inflammation and destruction in experimental immune complex-mediated arthritides not only by inhibition of FcgammaRI/III but also by efficient clearance and endocytosis of immune complexes.
van Lent P, Nabbe KC, Boross P, Blom AB, Roth J, Holthuysen A, Sloetjes A, Verbeek S, van den Berg W. van Lent P, et al. Am J Pathol. 2003 Nov;163(5):1839-48. doi: 10.1016/s0002-9440(10)63543-2. Am J Pathol. 2003. PMID: 14578184 Free PMC article.
Local IL-13 gene transfer prior to immune-complex arthritis inhibits chondrocyte death and matrix-metalloproteinase-mediated cartilage matrix degradation despite enhanced joint inflammation.
Nabbe KC, van Lent PL, Holthuysen AE, Sloëtjes AW, Koch AE, Radstake TR, van den Berg WB. Nabbe KC, et al. Among authors: holthuysen ae. Arthritis Res Ther. 2005;7(2):R392-401. doi: 10.1186/ar1502. Epub 2005 Jan 26. Arthritis Res Ther. 2005. PMID: 15743487 Free PMC article.
NADPH-oxidase-driven oxygen radical production determines chondrocyte death and partly regulates metalloproteinase-mediated cartilage matrix degradation during interferon-gamma-stimulated immune complex arthritis.
van Lent PL, Nabbe KC, Blom AB, Sloetjes A, Holthuysen AE, Kolls J, Van De Loo FA, Holland SM, Van Den Berg WB. van Lent PL, et al. Among authors: holthuysen ae. Arthritis Res Ther. 2005;7(4):R885-95. doi: 10.1186/ar1760. Epub 2005 May 20. Arthritis Res Ther. 2005. PMID: 15987491 Free PMC article.
Coordinate expression of activating Fc gamma receptors I and III and inhibiting Fc gamma receptor type II in the determination of joint inflammation and cartilage destruction during immune complex-mediated arthritis.
Nabbe KC, Blom AB, Holthuysen AE, Boross P, Roth J, Verbeek S, van Lent PL, van den Berg WB. Nabbe KC, et al. Among authors: holthuysen ae. Arthritis Rheum. 2003 Jan;48(1):255-65. doi: 10.1002/art.10721. Arthritis Rheum. 2003. PMID: 12528127 Free article.
28 results