Jia W - Search Results

1

A cavity-forming mutation in insulin induces segmental unfolding of a surrounding alpha-helix.

Xu B, Hua QX, Nakagawa SH, Jia W, Chu YC, Katsoyannis PG, Weiss MA. Xu B, et al. Among authors: jia w. Protein Sci. 2002 Jan;11(1):104-16. doi: 10.1110/ps.32102. Protein Sci. 2002. PMID: 11742127 Free PMC article.

2

Non-standard insulin design: structure-activity relationships at the periphery of the insulin receptor.

Weiss MA, Wan Z, Zhao M, Chu YC, Nakagawa SH, Burke GT, Jia W, Hellmich R, Katsoyannis PG. Weiss MA, et al. Among authors: jia w. J Mol Biol. 2002 Jan 11;315(2):103-11. doi: 10.1006/jmbi.2001.5224. J Mol Biol. 2002. PMID: 11779231

3

Protein structure and the spandrels of San Marco: insulin's receptor-binding surface is buttressed by an invariant leucine essential for its stability.

Weiss MA, Nakagawa SH, Jia W, Xu B, Hua QX, Chu YC, Wang RY, Katsoyannis PG. Weiss MA, et al. Among authors: jia w. Biochemistry. 2002 Jan 22;41(3):809-19. doi: 10.1021/bi011839+. Biochemistry. 2002. PMID: 11790102

4

Chiral mutagenesis of insulin's hidden receptor-binding surface: structure of an allo-isoleucine(A2) analogue.

Xu B, Hua QX, Nakagawa SH, Jia W, Chu YC, Katsoyannis PG, Weiss MA. Xu B, et al. Among authors: jia w. J Mol Biol. 2002 Feb 22;316(3):435-41. doi: 10.1006/jmbi.2001.5377. J Mol Biol. 2002. PMID: 11866509

5

Mechanism of insulin chain combination. Asymmetric roles of A-chain alpha-helices in disulfide pairing.

Hua QX, Chu YC, Jia W, Phillips NF, Wang RY, Katsoyannis PG, Weiss MA. Hua QX, et al. Among authors: jia w. J Biol Chem. 2002 Nov 8;277(45):43443-53. doi: 10.1074/jbc.M206107200. Epub 2002 Aug 23. J Biol Chem. 2002. PMID: 12196530 Free article.

6

A protein caught in a kinetic trap: structures and stabilities of insulin disulfide isomers.

Hua QX, Jia W, Frank BH, Phillips NF, Weiss MA. Hua QX, et al. Among authors: jia w. Biochemistry. 2002 Dec 17;41(50):14700-15. doi: 10.1021/bi0202981. Biochemistry. 2002. PMID: 12475219

7

A divergent INS protein in Caenorhabditis elegans structurally resembles human insulin and activates the human insulin receptor.

Hua QX, Nakagawa SH, Wilken J, Ramos RR, Jia W, Bass J, Weiss MA. Hua QX, et al. Among authors: jia w. Genes Dev. 2003 Apr 1;17(7):826-31. doi: 10.1101/gad.1058003. Epub 2003 Mar 21. Genes Dev. 2003. PMID: 12654724 Free PMC article.

8

A conserved histidine in insulin is required for the foldability of human proinsulin: structure and function of an ALAB5 analog.

Hua QX, Liu M, Hu SQ, Jia W, Arvan P, Weiss MA. Hua QX, et al. Among authors: jia w. J Biol Chem. 2006 Aug 25;281(34):24889-99. doi: 10.1074/jbc.M602617200. Epub 2006 May 25. J Biol Chem. 2006. PMID: 16728398 Free article.

9

Chiral mutagenesis of insulin. Contribution of the B20-B23 beta-turn to activity and stability.

Nakagawa SH, Hua QX, Hu SQ, Jia W, Wang S, Katsoyannis PG, Weiss MA. Nakagawa SH, et al. Among authors: jia w. J Biol Chem. 2006 Aug 4;281(31):22386-22396. doi: 10.1074/jbc.M603547200. Epub 2006 Jun 2. J Biol Chem. 2006. PMID: 16751187 Free article.

10

Toward the active conformation of insulin: stereospecific modulation of a structural switch in the B chain.

Hua QX, Nakagawa S, Hu SQ, Jia W, Wang S, Weiss MA. Hua QX, et al. Among authors: jia w. J Biol Chem. 2006 Aug 25;281(34):24900-9. doi: 10.1074/jbc.M602691200. Epub 2006 Jun 8. J Biol Chem. 2006. PMID: 16762918 Free article.

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