Freeman S - Search Results

1

Synthesis and enzymatic evaluation of pyridinium-substituted uracil derivatives as novel inhibitors of thymidine phosphorylase.

Murray PE, McNally VA, Lockyer SD, Williams KJ, Stratford IJ, Jaffar M, Freeman S. Murray PE, et al. Among authors: freeman s. Bioorg Med Chem. 2002 Mar;10(3):525-30. doi: 10.1016/s0968-0896(01)00309-1. Bioorg Med Chem. 2002. PMID: 11814838

2

The rôle of thymidine phosphorylase/PD-ECGF in cancer chemotherapy: a chemical perspective.

Cole C, Foster AJ, Freeman S, Jaffar M, Murray PE, Strafford IJ. Cole C, et al. Among authors: freeman s. Anticancer Drug Des. 1999 Oct;14(5):383-92. Anticancer Drug Des. 1999. PMID: 10766293 Review.

3

Cole C, Marks DS, Jaffar M, Stratford IJ, Douglas KT, Freeman S. Cole C, et al. Among authors: freeman s. Anticancer Drug Des. 1999 Oct;14(5):411-20. Anticancer Drug Des. 1999. PMID: 10766296

4

Stereochemistry at phosphorus of the reaction catalyzed by myo-inositol monophosphatase.

Fauroux CM, Lee M, Cullis PM, Douglas KT, Gore MG, Freeman S. Fauroux CM, et al. Among authors: freeman s. J Med Chem. 2002 Mar 14;45(6):1363-73. doi: 10.1021/jm011056m. J Med Chem. 2002. PMID: 11882005

5

Potential tumor-selective nitroimidazolylmethyluracil prodrug derivatives: inhibitors of the angiogenic enzyme thymidine phosphorylase.

Cole C, Reigan P, Gbaj A, Edwards PN, Douglas KT, Stratford IJ, Freeman S, Jaffar M. Cole C, et al. Among authors: freeman s. J Med Chem. 2003 Jan 16;46(2):207-9. doi: 10.1021/jm020964w. J Med Chem. 2003. PMID: 12519058

6

Identification of a novel class of inhibitor of human and Escherichia coli thymidine phosphorylase by in silico screening.

McNally VA, Gbaj A, Douglas KT, Stratford IJ, Jaffar M, Freeman S, Bryce RA. McNally VA, et al. Among authors: freeman s. Bioorg Med Chem Lett. 2003 Nov 3;13(21):3705-9. doi: 10.1016/j.bmcl.2003.08.010. Bioorg Med Chem Lett. 2003. PMID: 14552762

7

Synthesis and enzymatic evaluation of xanthine oxidase-activated prodrugs based on inhibitors of thymidine phosphorylase.

Reigan P, Gbaj A, Chinje E, Stratford IJ, Douglas KT, Freeman S. Reigan P, et al. Among authors: freeman s. Bioorg Med Chem Lett. 2004 Nov 1;14(21):5247-50. doi: 10.1016/j.bmcl.2004.08.036. Bioorg Med Chem Lett. 2004. PMID: 15454205

8

Aminoimidazolylmethyluracil analogues as potent inhibitors of thymidine phosphorylase and their bioreductive nitroimidazolyl prodrugs.

Reigan P, Edwards PN, Gbaj A, Cole C, Barry ST, Page KM, Ashton SE, Luke RW, Douglas KT, Stratford IJ, Jaffar M, Bryce RA, Freeman S. Reigan P, et al. Among authors: freeman s. J Med Chem. 2005 Jan 27;48(2):392-402. doi: 10.1021/jm049494r. J Med Chem. 2005. PMID: 15658853

9

Thymidine phosphorylase from Escherichia coli: tight-binding inhibitors as enzyme active-site titrants.

Gbaj A, Edwards PN, Reigan P, Freeman S, Jaffar M, Douglas KT. Gbaj A, et al. Among authors: freeman s. J Enzyme Inhib Med Chem. 2006 Feb;21(1):69-73. doi: 10.1080/14756360500424010. J Enzyme Inhib Med Chem. 2006. PMID: 16570508 Free article.

10

Design, synthesis and enzymatic evaluation of 6-bridged imidazolyluracil derivatives as inhibitors of human thymidine phosphorylase.

McNally VA, Rajabi M, Gbaj A, Stratford IJ, Edwards PN, Douglas KT, Bryce RA, Jaffar M, Freeman S. McNally VA, et al. Among authors: freeman s. J Pharm Pharmacol. 2007 Apr;59(4):537-47. doi: 10.1211/jpp.59.4.0008. J Pharm Pharmacol. 2007. PMID: 17430637

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