Becher MW - Search Results

1

Prolonged survival and decreased abnormal movements in transgenic model of Huntington disease, with administration of the transglutaminase inhibitor cystamine.

Karpuj MV, Becher MW, Springer JE, Chabas D, Youssef S, Pedotti R, Mitchell D, Steinman L. Karpuj MV, et al. Among authors: becher mw. Nat Med. 2002 Feb;8(2):143-9. doi: 10.1038/nm0202-143. Nat Med. 2002. PMID: 11821898

2

Evidence for a role for transglutaminase in Huntington's disease and the potential therapeutic implications.

Karpuj MV, Becher MW, Steinman L. Karpuj MV, et al. Among authors: becher mw. Neurochem Int. 2002 Jan;40(1):31-6. doi: 10.1016/s0197-0186(01)00060-2. Neurochem Int. 2002. PMID: 11738470 Review.

3

Transglutaminase aggregates huntingtin into nonamyloidogenic polymers, and its enzymatic activity increases in Huntington's disease brain nuclei.

Karpuj MV, Garren H, Slunt H, Price DL, Gusella J, Becher MW, Steinman L. Karpuj MV, et al. Among authors: becher mw. Proc Natl Acad Sci U S A. 1999 Jun 22;96(13):7388-93. doi: 10.1073/pnas.96.13.7388. Proc Natl Acad Sci U S A. 1999. PMID: 10377424 Free PMC article.

4

Huntington disease and the related disorder, dentatorubral-pallidoluysian atrophy (DRPLA).

Ross CA, Margolis RL, Rosenblatt A, Ranen NG, Becher MW, Aylward E. Ross CA, et al. Among authors: becher mw. Medicine (Baltimore). 1997 Sep;76(5):305-38. doi: 10.1097/00005792-199709000-00001. Medicine (Baltimore). 1997. PMID: 9352736 Free article. Review. No abstract available.

5

Intranuclear inclusions and neuritic aggregates in transgenic mice expressing a mutant N-terminal fragment of huntingtin.

Schilling G, Becher MW, Sharp AH, Jinnah HA, Duan K, Kotzuk JA, Slunt HH, Ratovitski T, Cooper JK, Jenkins NA, Copeland NG, Price DL, Ross CA, Borchelt DR. Schilling G, et al. Among authors: becher mw. Hum Mol Genet. 1999 Mar;8(3):397-407. doi: 10.1093/hmg/8.3.397. Hum Mol Genet. 1999. PMID: 9949199

6

Intranuclear neuronal inclusions in Huntington's disease and dentatorubral and pallidoluysian atrophy: correlation between the density of inclusions and IT15 CAG triplet repeat length.

Becher MW, Kotzuk JA, Sharp AH, Davies SW, Bates GP, Price DL, Ross CA. Becher MW, et al. Neurobiol Dis. 1998 Apr;4(6):387-97. doi: 10.1006/nbdi.1998.0168. Neurobiol Dis. 1998. PMID: 9666478 Free article.

7

Elevated free nitrotyrosine levels, but not protein-bound nitrotyrosine or hydroxyl radicals, throughout amyotrophic lateral sclerosis (ALS)-like disease implicate tyrosine nitration as an aberrant in vivo property of one familial ALS-linked superoxide dismutase 1 mutant.

Bruijn LI, Beal MF, Becher MW, Schulz JB, Wong PC, Price DL, Cleveland DW. Bruijn LI, et al. Among authors: becher mw. Proc Natl Acad Sci U S A. 1997 Jul 8;94(14):7606-11. doi: 10.1073/pnas.94.14.7606. Proc Natl Acad Sci U S A. 1997. PMID: 9207139 Free PMC article.

8

Expansion of polyglutamine repeat in huntingtin leads to abnormal protein interactions involving calmodulin.

Bao J, Sharp AH, Wagster MV, Becher M, Schilling G, Ross CA, Dawson VL, Dawson TM. Bao J, et al. Proc Natl Acad Sci U S A. 1996 May 14;93(10):5037-42. doi: 10.1073/pnas.93.10.5037. Proc Natl Acad Sci U S A. 1996. PMID: 8643525 Free PMC article.

9

Inherited neurodegenerative diseases and transgenic models.

Price DL, Becher MW, Wong PC, Borchelt DR, Lee MK, Sisodia SS. Price DL, et al. Among authors: becher mw. Brain Pathol. 1996 Oct;6(4):467-80. doi: 10.1111/j.1750-3639.1996.tb00876.x. Brain Pathol. 1996. PMID: 8944317 Review.

10

Kearns-Sayre syndrome with features of Pearson's marrow-pancreas syndrome and a novel 2905-base pair mitochondrial DNA deletion.

Becher MW, Wills ML, Noll WW, Hurko O, Price DL. Becher MW, et al. Hum Pathol. 1999 May;30(5):577-81. doi: 10.1016/s0046-8177(99)90204-6. Hum Pathol. 1999. PMID: 10333230

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