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Nasal insulin to prevent type 1 diabetes in children with HLA genotypes and autoantibodies conferring increased risk of disease: a double-blind, randomised controlled trial.
Näntö-Salonen K, Kupila A, Simell S, Siljander H, Salonsaari T, Hekkala A, Korhonen S, Erkkola R, Sipilä JI, Haavisto L, Siltala M, Tuominen J, Hakalax J, Hyöty H, Ilonen J, Veijola R, Simell T, Knip M, Simell O. Näntö-Salonen K, et al. Among authors: simell t, simell s, simell o. Lancet. 2008 Nov 15;372(9651):1746-55. doi: 10.1016/S0140-6736(08)61309-4. Epub 2008 Sep 22. Lancet. 2008. PMID: 18814906 Clinical Trial.
Impact of intranasal insulin on insulin antibody affinity and isotypes in young children with HLA-conferred susceptibility to type 1 diabetes.
Ryhänen SJ, Härkönen T, Siljander H, Näntö-Salonen K, Simell T, Hyöty H, Ilonen J, Veijola R, Simell O, Knip M. Ryhänen SJ, et al. Among authors: simell t, simell o. Diabetes Care. 2011 Jun;34(6):1383-8. doi: 10.2337/dc10-1449. Epub 2011 Apr 22. Diabetes Care. 2011. PMID: 21515841 Free PMC article. Clinical Trial.
Coxsackievirus B1 is associated with induction of β-cell autoimmunity that portends type 1 diabetes.
Laitinen OH, Honkanen H, Pakkanen O, Oikarinen S, Hankaniemi MM, Huhtala H, Ruokoranta T, Lecouturier V, André P, Harju R, Virtanen SM, Lehtonen J, Almond JW, Simell T, Simell O, Ilonen J, Veijola R, Knip M, Hyöty H. Laitinen OH, et al. Among authors: simell t, simell o. Diabetes. 2014 Feb;63(2):446-55. doi: 10.2337/db13-0619. Epub 2013 Aug 23. Diabetes. 2014. PMID: 23974921
Innate immune activity is detected prior to seroconversion in children with HLA-conferred type 1 diabetes susceptibility.
Kallionpää H, Elo LL, Laajala E, Mykkänen J, Ricaño-Ponce I, Vaarma M, Laajala TD, Hyöty H, Ilonen J, Veijola R, Simell T, Wijmenga C, Knip M, Lähdesmäki H, Simell O, Lahesmaa R. Kallionpää H, et al. Among authors: simell t, simell o. Diabetes. 2014 Jul;63(7):2402-14. doi: 10.2337/db13-1775. Epub 2014 Feb 18. Diabetes. 2014. PMID: 24550192 Free article.
Role of Type 1 Diabetes-Associated SNPs on Risk of Autoantibody Positivity in the TEDDY Study.
Törn C, Hadley D, Lee HS, Hagopian W, Lernmark Å, Simell O, Rewers M, Ziegler A, Schatz D, Akolkar B, Onengut-Gumuscu S, Chen WM, Toppari J, Mykkänen J, Ilonen J, Rich SS, She JX, Steck AK, Krischer J; TEDDY Study Group. Törn C, et al. Diabetes. 2015 May;64(5):1818-29. doi: 10.2337/db14-1497. Epub 2014 Nov 24. Diabetes. 2015. PMID: 25422107 Free PMC article.
90 results