Sausville EA - Search Results

1

Perifosine, a novel alkylphospholipid, induces p21(WAF1) expression in squamous carcinoma cells through a p53-independent pathway, leading to loss in cyclin-dependent kinase activity and cell cycle arrest.

Patel V, Lahusen T, Sy T, Sausville EA, Gutkind JS, Senderowicz AM. Patel V, et al. Among authors: sausville ea. Cancer Res. 2002 Mar 1;62(5):1401-9. Cancer Res. 2002. PMID: 11888912

2

Mammalian target of rapamycin, a molecular target in squamous cell carcinomas of the head and neck.

Amornphimoltham P, Patel V, Sodhi A, Nikitakis NG, Sauk JJ, Sausville EA, Molinolo AA, Gutkind JS. Amornphimoltham P, et al. Among authors: sausville ea. Cancer Res. 2005 Nov 1;65(21):9953-61. doi: 10.1158/0008-5472.CAN-05-0921. Cancer Res. 2005. PMID: 16267020

3

Antitumor activity of UCN-01 in carcinomas of the head and neck is associated with altered expression of cyclin D3 and p27(KIP1).

Patel V, Lahusen T, Leethanakul C, Igishi T, Kremer M, Quintanilla-Martinez L, Ensley JF, Sausville EA, Gutkind JS, Senderowicz AM. Patel V, et al. Among authors: sausville ea. Clin Cancer Res. 2002 Nov;8(11):3549-60. Clin Cancer Res. 2002. PMID: 12429646

4

Flavopiridol-related proinflammatory syndrome is associated with induction of interleukin-6.

Messmann RA, Ullmann CD, Lahusen T, Kalehua A, Wasfy J, Melillo G, Ding I, Headlee D, Figg WD, Sausville EA, Senderowicz AM. Messmann RA, et al. Among authors: sausville ea. Clin Cancer Res. 2003 Feb;9(2):562-70. Clin Cancer Res. 2003. PMID: 12576419 Clinical Trial.

5

Persistent activation of the Akt pathway in head and neck squamous cell carcinoma: a potential target for UCN-01.

Amornphimoltham P, Sriuranpong V, Patel V, Benavides F, Conti CJ, Sauk J, Sausville EA, Molinolo AA, Gutkind JS. Amornphimoltham P, et al. Among authors: sausville ea. Clin Cancer Res. 2004 Jun 15;10(12 Pt 1):4029-37. doi: 10.1158/1078-0432.CCR-03-0249. Clin Cancer Res. 2004. PMID: 15217935

6

Flavopiridol, a novel cyclin-dependent kinase inhibitor, suppresses the growth of head and neck squamous cell carcinomas by inducing apoptosis.

Patel V, Senderowicz AM, Pinto D Jr, Igishi T, Raffeld M, Quintanilla-Martinez L, Ensley JF, Sausville EA, Gutkind JS. Patel V, et al. Among authors: sausville ea. J Clin Invest. 1998 Nov 1;102(9):1674-81. doi: 10.1172/JCI3661. J Clin Invest. 1998. PMID: 9802881 Free PMC article.

7

Discovery and initial characterization of the paullones, a novel class of small-molecule inhibitors of cyclin-dependent kinases.

Zaharevitz DW, Gussio R, Leost M, Senderowicz AM, Lahusen T, Kunick C, Meijer L, Sausville EA. Zaharevitz DW, et al. Among authors: sausville ea. Cancer Res. 1999 Jun 1;59(11):2566-9. Cancer Res. 1999. PMID: 10363974

8

Down-regulation of cyclin D1 by transcriptional repression in MCF-7 human breast carcinoma cells induced by flavopiridol.

Carlson B, Lahusen T, Singh S, Loaiza-Perez A, Worland PJ, Pestell R, Albanese C, Sausville EA, Senderowicz AM. Carlson B, et al. Among authors: sausville ea. Cancer Res. 1999 Sep 15;59(18):4634-41. Cancer Res. 1999. PMID: 10493518

9

Flavopiridol, a protein kinase inhibitor, down-regulates hypoxic induction of vascular endothelial growth factor expression in human monocytes.

Melillo G, Sausville EA, Cloud K, Lahusen T, Varesio L, Senderowicz AM. Melillo G, et al. Among authors: sausville ea. Cancer Res. 1999 Nov 1;59(21):5433-7. Cancer Res. 1999. PMID: 10554012

10

Preclinical and clinical development of cyclin-dependent kinase modulators.

Senderowicz AM, Sausville EA. Senderowicz AM, et al. Among authors: sausville ea. J Natl Cancer Inst. 2000 Mar 1;92(5):376-87. doi: 10.1093/jnci/92.5.376. J Natl Cancer Inst. 2000. PMID: 10699068 Review.

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