Saftig P - Search Results

1

A physiologic signaling role for the gamma -secretase-derived intracellular fragment of APP.

Leissring MA, Murphy MP, Mead TR, Akbari Y, Sugarman MC, Jannatipour M, Anliker B, Müller U, Saftig P, De Strooper B, Wolfe MS, Golde TE, LaFerla FM. Leissring MA, et al. Among authors: saftig p. Proc Natl Acad Sci U S A. 2002 Apr 2;99(7):4697-702. doi: 10.1073/pnas.072033799. Epub 2002 Mar 26. Proc Natl Acad Sci U S A. 2002. PMID: 11917117 Free PMC article.

2

Amyloidogenic processing of human amyloid precursor protein in hippocampal neurons devoid of cathepsin D.

Saftig P, Peters C, von Figura K, Craessaerts K, Van Leuven F, De Strooper B. Saftig P, et al. J Biol Chem. 1996 Nov 1;271(44):27241-4. doi: 10.1074/jbc.271.44.27241. J Biol Chem. 1996. PMID: 8910296 Free article.

3

Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein.

De Strooper B, Saftig P, Craessaerts K, Vanderstichele H, Guhde G, Annaert W, Von Figura K, Van Leuven F. De Strooper B, et al. Among authors: saftig p. Nature. 1998 Jan 22;391(6665):387-90. doi: 10.1038/34910. Nature. 1998. PMID: 9450754

4

Downregulation of PS1 expression in neurons decreases beta-amyloid production: a biochemical link between the two major familial Alzheimer's disease genes.

Saftig P, de Strooper B. Saftig P, et al. Mol Psychiatry. 1998 Jul;3(4):287-9. doi: 10.1038/sj.mp.4000408. Mol Psychiatry. 1998. PMID: 9702732 No abstract available.

5

A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain.

De Strooper B, Annaert W, Cupers P, Saftig P, Craessaerts K, Mumm JS, Schroeter EH, Schrijvers V, Wolfe MS, Ray WJ, Goate A, Kopan R. De Strooper B, et al. Among authors: saftig p. Nature. 1999 Apr 8;398(6727):518-22. doi: 10.1038/19083. Nature. 1999. PMID: 10206645

6

Presenilin-1 deficiency leads to loss of Cajal-Retzius neurons and cortical dysplasia similar to human type 2 lissencephaly.

Hartmann D, De Strooper B, Saftig P. Hartmann D, et al. Among authors: saftig p. Curr Biol. 1999 Jul 15;9(14):719-27. doi: 10.1016/s0960-9822(99)80331-5. Curr Biol. 1999. PMID: 10421573 Free article.

7

Presenilin 2 deficiency causes a mild pulmonary phenotype and no changes in amyloid precursor protein processing but enhances the embryonic lethal phenotype of presenilin 1 deficiency.

Herreman A, Hartmann D, Annaert W, Saftig P, Craessaerts K, Serneels L, Umans L, Schrijvers V, Checler F, Vanderstichele H, Baekelandt V, Dressel R, Cupers P, Huylebroeck D, Zwijsen A, Van Leuven F, De Strooper B. Herreman A, et al. Among authors: saftig p. Proc Natl Acad Sci U S A. 1999 Oct 12;96(21):11872-7. doi: 10.1073/pnas.96.21.11872. Proc Natl Acad Sci U S A. 1999. PMID: 10518543 Free PMC article.

8

Cell surface presenilin-1 participates in the gamma-secretase-like proteolysis of Notch.

Ray WJ, Yao M, Mumm J, Schroeter EH, Saftig P, Wolfe M, Selkoe DJ, Kopan R, Goate AM. Ray WJ, et al. Among authors: saftig p. J Biol Chem. 1999 Dec 17;274(51):36801-7. doi: 10.1074/jbc.274.51.36801. J Biol Chem. 1999. PMID: 10593990 Free article.

9

The function of presenilin-1 in amyloid beta-peptide generation and brain development.

Saftig P, Hartmann D, De Strooper B. Saftig P, et al. Eur Arch Psychiatry Clin Neurosci. 1999;249(6):271-9. doi: 10.1007/s004060050099. Eur Arch Psychiatry Clin Neurosci. 1999. PMID: 10653282 Review.

10

Presenilin function in APP processing.

Annaert W, Cupers P, Saftig P, De Strooper B. Annaert W, et al. Among authors: saftig p. Ann N Y Acad Sci. 2000;920:158-64. doi: 10.1111/j.1749-6632.2000.tb06917.x. Ann N Y Acad Sci. 2000. PMID: 11193144 Review.

Save citations to file

Email citations

Send citations to clipboard

Add to Collections

Add to My Bibliography

Create a file for external citation management software

Your saved search

Your RSS Feed

My Custom Filters

Publication date

Text availability

Article attribute

Article type

Article Language

Species

Sex

Age

Other

346 results

Search Page

Filters