Bledsoe RK - Search Results

1

Crystal structure of the glucocorticoid receptor ligand binding domain reveals a novel mode of receptor dimerization and coactivator recognition.

Bledsoe RK, Montana VG, Stanley TB, Delves CJ, Apolito CJ, McKee DD, Consler TG, Parks DJ, Stewart EL, Willson TM, Lambert MH, Moore JT, Pearce KH, Xu HE. Bledsoe RK, et al. Cell. 2002 Jul 12;110(1):93-105. doi: 10.1016/s0092-8674(02)00817-6. Cell. 2002. PMID: 12151000 Free article.

2

X-ray crystal structure of the liver X receptor beta ligand binding domain: regulation by a histidine-tryptophan switch.

Williams S, Bledsoe RK, Collins JL, Boggs S, Lambert MH, Miller AB, Moore J, McKee DD, Moore L, Nichols J, Parks D, Watson M, Wisely B, Willson TM. Williams S, et al. Among authors: bledsoe rk. J Biol Chem. 2003 Jul 18;278(29):27138-43. doi: 10.1074/jbc.M302260200. Epub 2003 May 7. J Biol Chem. 2003. PMID: 12736258 Free article.

3

Structure and function of the glucocorticoid receptor ligand binding domain.

Bledsoe RK, Stewart EL, Pearce KH. Bledsoe RK, et al. Vitam Horm. 2004;68:49-91. doi: 10.1016/S0083-6729(04)68002-2. Vitam Horm. 2004. PMID: 15193451 Review.

4

A ligand-mediated hydrogen bond network required for the activation of the mineralocorticoid receptor.

Bledsoe RK, Madauss KP, Holt JA, Apolito CJ, Lambert MH, Pearce KH, Stanley TB, Stewart EL, Trump RP, Willson TM, Williams SP. Bledsoe RK, et al. J Biol Chem. 2005 Sep 2;280(35):31283-93. doi: 10.1074/jbc.M504098200. Epub 2005 Jun 20. J Biol Chem. 2005. PMID: 15967794 Free article.

5

Asymmetry in the PPARgamma/RXRalpha crystal structure reveals the molecular basis of heterodimerization among nuclear receptors.

Gampe RT Jr, Montana VG, Lambert MH, Miller AB, Bledsoe RK, Milburn MV, Kliewer SA, Willson TM, Xu HE. Gampe RT Jr, et al. Among authors: bledsoe rk. Mol Cell. 2000 Mar;5(3):545-55. doi: 10.1016/s1097-2765(00)80448-7. Mol Cell. 2000. PMID: 10882139 Free article.

6

Expression, purification, and characterization of multiple, multifunctional human glucocorticoid receptor proteins.

Simmons CA, Bledsoe RK, Guex N, Pearce KH. Simmons CA, et al. Among authors: bledsoe rk. Protein Expr Purif. 2008 Nov;62(1):29-35. doi: 10.1016/j.pep.2008.07.008. Epub 2008 Jul 30. Protein Expr Purif. 2008. PMID: 18694832

7

Functional consequences of cysteine modification in the ligand binding sites of peroxisome proliferator activated receptors by GW9662.

Leesnitzer LM, Parks DJ, Bledsoe RK, Cobb JE, Collins JL, Consler TG, Davis RG, Hull-Ryde EA, Lenhard JM, Patel L, Plunket KD, Shenk JL, Stimmel JB, Therapontos C, Willson TM, Blanchard SG. Leesnitzer LM, et al. Among authors: bledsoe rk. Biochemistry. 2002 May 28;41(21):6640-50. doi: 10.1021/bi0159581. Biochemistry. 2002. PMID: 12022867

8

The first X-ray crystal structure of the glucocorticoid receptor bound to a non-steroidal agonist.

Madauss KP, Bledsoe RK, Mclay I, Stewart EL, Uings IJ, Weingarten G, Williams SP. Madauss KP, et al. Among authors: bledsoe rk. Bioorg Med Chem Lett. 2008 Dec 1;18(23):6097-9. doi: 10.1016/j.bmcl.2008.10.021. Epub 2008 Oct 8. Bioorg Med Chem Lett. 2008. PMID: 18952422

9

Bile acids: natural ligands for an orphan nuclear receptor.

Parks DJ, Blanchard SG, Bledsoe RK, Chandra G, Consler TG, Kliewer SA, Stimmel JB, Willson TM, Zavacki AM, Moore DD, Lehmann JM. Parks DJ, et al. Among authors: bledsoe rk. Science. 1999 May 21;284(5418):1365-8. doi: 10.1126/science.284.5418.1365. Science. 1999. PMID: 10334993

10

Orphan nuclear receptors constitutive androstane receptor and pregnane X receptor share xenobiotic and steroid ligands.

Moore LB, Parks DJ, Jones SA, Bledsoe RK, Consler TG, Stimmel JB, Goodwin B, Liddle C, Blanchard SG, Willson TM, Collins JL, Kliewer SA. Moore LB, et al. Among authors: bledsoe rk. J Biol Chem. 2000 May 19;275(20):15122-7. doi: 10.1074/jbc.M001215200. J Biol Chem. 2000. PMID: 10748001 Free article.

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