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SB-656104-A: a novel 5-HT(7) receptor antagonist with improved in vivo properties.
Forbes IT, Douglas S, Gribble AD, Ife RJ, Lightfoot AP, Garner AE, Riley GJ, Jeffrey P, Stevens AJ, Stean TO, Thomas DR. Forbes IT, et al. Among authors: gribble ad. Bioorg Med Chem Lett. 2002 Nov 18;12(22):3341-4. doi: 10.1016/s0960-894x(02)00690-x. Bioorg Med Chem Lett. 2002. PMID: 12392747
Identification of a novel series of selective 5-HT7 receptor antagonists.
Forbes IT, Cooper DG, Dodds EK, Douglas SE, Gribble AD, Ife RJ, Lightfoot AP, Meeson M, Campbell LP, Coleman T, Riley GJ, Thomas DR. Forbes IT, et al. Among authors: gribble ad. Bioorg Med Chem Lett. 2003 Mar 24;13(6):1055-8. doi: 10.1016/s0960-894x(03)00077-5. Bioorg Med Chem Lett. 2003. PMID: 12643910
SB-656104-A, a novel selective 5-HT7 receptor antagonist, modulates REM sleep in rats.
Thomas DR, Melotto S, Massagrande M, Gribble AD, Jeffrey P, Stevens AJ, Deeks NJ, Eddershaw PJ, Fenwick SH, Riley G, Stean T, Scott CM, Hill MJ, Middlemiss DN, Hagan JJ, Price GW, Forbes IT. Thomas DR, et al. Among authors: gribble ad. Br J Pharmacol. 2003 Jun;139(4):705-14. doi: 10.1038/sj.bjp.0705290. Br J Pharmacol. 2003. PMID: 12812993 Free PMC article.
Studies towards the identification of a new generation of atypical antipsychotic agents.
Garzya V, Forbes IT, Gribble AD, Hadley MS, Lightfoot AP, Payne AH, Smith AB, Douglas SE, Cooper DG, Stansfield IG, Meeson M, Dodds EE, Jones DN, Wood M, Reavill C, Scorer CA, Worby A, Riley G, Eddershaw P, Ioannou C, Donati D, Hagan JJ, Ratti EA. Garzya V, et al. Among authors: gribble ad. Bioorg Med Chem Lett. 2007 Jan 15;17(2):400-5. doi: 10.1016/j.bmcl.2006.10.036. Epub 2006 Oct 19. Bioorg Med Chem Lett. 2007. PMID: 17084080
ATP-Citrate lyase as a target for hypolipidemic intervention. 2. Synthesis and evaluation of (3R,5S)-omega-substituted-3-carboxy-3, 5-dihydroxyalkanoic acids and their gamma-lactone prodrugs as inhibitors of the enzyme in vitro and in vivo.
Gribble AD, Ife RJ, Shaw A, McNair D, Novelli CE, Bakewell S, Shah VP, Dolle RE, Groot PH, Pearce N, Yates J, Tew D, Boyd H, Ashman S, Eggleston DS, Haltiwanger RC, Okafo G. Gribble AD, et al. J Med Chem. 1998 Sep 10;41(19):3582-95. doi: 10.1021/jm980091z. J Med Chem. 1998. PMID: 9733484
20 results